- B.Sc., University of British Columbia
- M.Sc., Simon Fraser University
- Ph.D., Simon Fraser University
We are interested in understanding the molecular mechanisms underpinning bacterial virulence. How do bacteria assemble and secrete virulence factors that allow them to colonise a host and cause disease? We apply x-ray crystallography, electron microscopy and genetic analysis to obtain atomic level structure/function information on molecules and molecular machines that impart virulence on bacterial pathogens. This information will guide the development of antimicrobial therapies aimed to disarm rather than kill bacteria in order to minimize antibiotic resistance.
- Gutierrez-Rodarte, M., Kolappan, S., Burrell, B. and Craig, L. (2019) The Vibrio cholerae minor pilin TcpB mediates uptake of the cholera toxin phage CTXf. J Biol Chem, 294, 15698-15710, PMID: 31471320. http://www.jbc.org/content/294/43/15698.full?sid=e9257e27-c932-45d8-9700-1dcc34891b4d
- Craig, L., Forest, K.T. and Maier, B.T. (2019). Type IV pili: dynamics, biophysics and functional consequences. Nat Rev Microbiol 17, PMID: 30988511. https://www.nature.com/articles/s41579-019-0195-4
- Kolappan, S, Ng, D, Yang, G, Harn, T and Craig, L (2015). Crystal Structure of the minor pilin CofB, the initiator of CFA/III pilus assembly in enterotoxigenic Escherichia coli. J. Biol Chem, 290, 25805-25818. http://www.jbc.org/content/290/43/25805.long