Our research uses molecular and cell biology approaches to investigate HIV-1 pathogenesis and the human cellular immune response to viral infection.
The Brockman lab has developed in vitro methods that support unique population-level analyses of HIV virology and immunology, contributing to global efforts to discover an effective vaccine or cure for HIV. Current studies focus on understanding the impact of viral immune escape mutations on HIV protein function and cytotoxic T lymphocyte recognition, assessing the role of HIV accessory proteins in establishment and maintenance of viral latency, and employing new assays to identify patient-derived T cell receptors that recognize HIV-infected target cells.
For more information, visit our research lab website.
- Ogunshola, Anmole, et al. (2018) Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV Gag escape variants. Nature Communications (Accepted)
- Alsahafi et al. (2017) Impaired downregulation of NKG2D ligands by Nef protein from elite controllers sensitize HIV-1-infected cells to ADCC. Journal of Virology 91(16):e00109-17. doi: 10.1128/JVI.00109-17
- Mwimanzi et al. (2016) Novel acylguanidine-based inhibitor of HIV-1. Journal of Virology 90(20):9495-508. doi: 10.1128/JVI.01107-16
- Cotton, Kuang, Le et al. (2014) Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic. PLoS Genetics 10(4):e1004295. doi: 10.1371/journal.pgen.1004295
- Kuang et al. (2014) Impaired Nef function is associated with early control of HIV-1 viremia. Journal of Virology 88(17):10200-13. doi: 10.1128/JVI.01334-14