Our research uses molecular and cell biology approaches to investigate HIV-1 pathogenesis and the human cellular immune response to viral infection.
The Brockman lab has developed in vitro methods that support unique population-level analyses of HIV virology and immunology, contributing to global efforts to discover an effective vaccine or cure for HIV. Current studies focus on understanding the impact of viral immune escape mutations on HIV protein function and cytotoxic T lymphocyte recognition, assessing the role of HIV accessory proteins in establishment and maintenance of viral latency, and employing new assays to identify patient-derived T cell receptors that recognize HIV-infected target cells.
For more information, visit our research lab website.
- Kuang et al. Impaired Nef function is associated with early control of HIV-1 viremia. Journal of Virology, 2014
- Anmole et al. A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion. J Immunol Methods 2015 (doi: 10.1016/j.jim.2015.08.010)
- Brockman et al. Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs. Front Immunol 2015 (doi: 10.3389/fimmu.2015.00506)