Paetzel Lab

We investigate enzyme structure and mechanism.

Our lab uses molecular biology, protein chemistry, X-ray crystallography and other physical methods to investigate the structure and catalytic mechanism of enzymes. Currently we have many project related to viral protease self-processing, compartmentalized proteases, and eukaryotic membrane bound proteases.

For more details, visit our research lab website.



Lab Room: 

SSB 6156

Lab Phone:

(778) 782-4318

Selected Publications: 

  • Zhang et. al. Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein-C and its Hypertrophic Cardiomyopathy-Related R502W Mutant. Biochemistry 2014
  • Nam & Paetzel. Structure of signal peptide peptidase A with C-termini bound in the active sites: insights into specificity, self-processing and regulation. Biochemistry 2013
  • Chung & Paetzel. Crystal structure of Yellowtail ascites virus VP4 protease: trapping an internal cleavage site trans acyl-enzyme complex in a native Ser/Lys dyad active site. J Biol Chem 2013

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