We investigate enzyme structure and mechanism.
Our lab uses molecular biology, protein chemistry, X-ray crystallography and other physical methods to investigate the structure and catalytic mechanism of enzymes. Currently we have many project related to viral protease self-processing, compartmentalized proteases, and eukaryotic membrane bound proteases.
For more details, visit our research lab website.
- Zhang et. al. Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein-C and its Hypertrophic Cardiomyopathy-Related R502W Mutant. Biochemistry 2014
- Nam & Paetzel. Structure of signal peptide peptidase A with C-termini bound in the active sites: insights into specificity, self-processing and regulation. Biochemistry 2013
- Chung & Paetzel. Crystal structure of Yellowtail ascites virus VP4 protease: trapping an internal cleavage site trans acyl-enzyme complex in a native Ser/Lys dyad active site. J Biol Chem 2013