In the Verheyen lab we use molecular, genetic and biochemical approaches to understand organismal growth and patterning.
Specifically, we are interested in how cells control their growth and how certain tissues regulate their pattern formation. To do this, we use Drosophila melanogaster, the fruit fly, as a genetic model organism. Our studies allow us to ask questions about how cells respond to cues from neighboring cells. We are interested in how these processes are regulated by reversible phosphorylation of proteins. Our goal is to gain an understanding of the mechanisms used by cells to ensure properly regulated growth and tissue formation. Currently we are studying how the kinase called Hipk can promote tumorigenesis and how kinases and protein phosphatases regulate Wnt/Wingless signaling during essential developmental processes.
For more details, visit our research lab website.
- Blaquiere, J.A., Wong, K.L., Kinsey, S., Wu, J. and E.M. Verheyen (2018) Homeodomain interacting protein kinase promotes tumorigenesis and metastatic cell behavior. Disease Models and Mechanisms 11: dmm031146. Selected for cover image
- Hall, E.T., Pradhan-Sundd, T., Samnani, F. and E.M. Verheyen (2017) The Protein Phosphatase 4 complex promotes the Notch pathway and wingless transcription. Published in Biology Open 6:1165-1173.
- Blaquiere, J.A. and E.M. Verheyen (2017) Homeodomain-interacting protein kinases (Hipks): Diverse and complex roles in development and disease. Invited review in volume entitled "Protein Kinases in Development and Disease". Current Topics in Developmental Biology, 123:73-103.
- Sulkowski, M.J., Han, T.H., Ott, C., Wang, Q., Verheyen, E.M., Lippincott-Schwartz, J., and M. Serpa (2016) A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction. PLoS Genet 12(1): e1005810.