Simon Fraser University
Engaging the World

Course Outlines

Spring 2015 - MBB 423 D100

Protein Structure and Function (3)

Class Number: 5092

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 6 – Apr 13, 2015: Tue, 8:30–10:20 a.m.
    Burnaby

    Jan 6 – Apr 13, 2015: Thu, 8:30–9:20 a.m.
    Burnaby

  • Exam Times + Location:

    Apr 21, 2015
    Tue, 12:00–3:00 p.m.
    Burnaby

  • Prerequisites:

    two of MBB 321, 322, 323, 331, with a minimum grade of C.

Description

CALENDAR DESCRIPTION:

Recent research in transition state theory; specificity in enzyme catalyzed reactions, the use of recombinant DNA techniques to describe and modify enzyme catalysis, the function of enzymes in organic solvents, and the development of new catalytic activities through monoclonal antibody techniques.

COURSE DETAILS:

3 lecture hours + 1 tutorial hour / week
Through examination of modern research literature, students will learn to assess primary literature reports of structure data, and to formulate hypotheses and apply structural reasoning in investigations of molecular mechanism

Topics
 
Structural basis of protein function: 

  • Stability and flexibility     
  • Enzymatic catalysis    
  • Integrating multiple functions
Obtaining and assessing structural data:
  • X-ray crystallography     
  • Electron microscopy     
  • Spectroscopic techniques

Grading

  • Quizzes/Clicker 15%
  • Midterm Exam I 15%
  • Written Assignment 15%
  • Midterm Exam II 15%
  • Final Exam 40%
  • Grading is subject to change depending on enrolment.

Materials

MATERIALS + SUPPLIES:

iClicker transmitter required during lectures (available from SFU Bookstore).

REQUIRED READING:

This course is not textbook-based. Course readings and research journal articles will be available in Library Reserves.

Department Undergraduate Notes:

  • Students are advised to review the plagiarism tutorial found at
    http://www.lib.sfu.ca/help/tutorials/plagiarism-tutorial
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
    http://learningcommons.sfu.ca/
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS