Fall 2019 - CHEM 452 D100
Bio-organic Chemistry (3)
Class Number: 10691
Delivery Method: In Person
Course Times + Location:
Tu, Th 2:30 PM – 4:20 PM
AQ 5006, Burnaby
Exam Times + Location:
Dec 11, 2019
3:30 PM – 6:30 PM
AQ 5019, Burnaby
Prerequisites:CHEM 380 and MBB 222, both with a minimum grade of C-, or permission of the Department.
An advanced treatment of the use of enzymes in organic synthesis, the use of stable and radioisotopes in the study of enzymatic processes and the design of enzyme inhibitors. Quantitative.
This course will provide an overview of natural products and their biosynthetic origin. The course will begin with the synthetic building blocks and strategies used in living systems. Next, we shall cover primary metabolic pathways and later move on to complex secondary metabolites. Behind the bewildering complexity and variety of natural product biosyntheses there are a few elegant recurring patterns, which we shall highlight.
1. Biochemical "reagents": nucleotide triphosphates, nicotinamide cofactors, flavins, coenzyme A, lipoic acid, pyridoxamine/pyridoxal, thiamine phosphate, biotin, folate, vitamin B12, S-adenosyl methionine
2. Primary metabolism: carbohydrates
4. Proteins and peptides
5. Fatty acids
6. Polyketides and phenolics
8. The Shikimate pathway: another route to phenolics
- Midterm Exam (Open Book) 20%
- Term Paper 40%
- Final Exam (Open Book) 40%
MATERIALS + SUPPLIES:
Dewick. Medicinal Natural Products: A Biosynthetic Approach. 3rd Ed. 2009. Publisher: Wiley.
Mann, Harborne and Davidson. Natural Products: Their Chemistry and Biological Significance. 1994. Publisher: Longman Publishing Group.
Michal & Schomburg. Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology. Publisher: Wiley.
Department Undergraduate Notes:
A grade of C- or better is required for all prerequisite courses.
SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.
Each student is responsible for his or her conduct as it affects the University community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS