Simon Fraser University
Engaging the World

Course Outlines

Fall 2022 - MBB 723 G100

Protein Structure and Function (3)

Class Number: 2289

Delivery Method: In Person

Overview

  • Course Times + Location:

    Sep 7 – Dec 6, 2022: Wed, 10:30 a.m.–12:20 p.m.
    Burnaby

    Sep 7 – Dec 6, 2022: Fri, 10:30 a.m.–12:20 p.m.
    Burnaby

Description

CALENDAR DESCRIPTION:

Mechanistic principles for how protein molecules achieve diverse functions such as chemical catalysis and conformational switching. Students will learn to critique hypotheses about structural mechanisms, and to interpret the primary literature reporting on structural evidence from X-ray diffraction and spectroscopy.

COURSE DETAILS:

This course will begin with a review of basic protein structure principles and move into advanced mechanistic principles for how protein molecules achieve diverse functions such as chemical catalysis and conformational switching.  The course will discuss topics that are at the frontier of the protein structure-function field, with a focus on how protein structure underlies biological function, especially in the context of health and disease.  The course has an equal emphasis on principles of protein structure-function as well as the diverse methodologies used to examine protein structure-function. Students will learn to critique hypotheses about structural mechanisms, and to interpret the primary literature reporting on structural evidence from a variety of classical and emerging methodologies.

Grading

  • Two timed exams (worth 20% and 30% respectively) 50%
  • Class presentations and participation 20%
  • Final written assignment 30%

Materials

REQUIRED READING:

This course is not textbook-based. Course readings and research journal articles will be available in electronic Library Reserves or Canvas.

REQUIRED READING NOTES:

Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Graduate Studies Notes:

Important dates and deadlines for graduate students are found here: http://www.sfu.ca/dean-gradstudies/current/important_dates/guidelines.html. The deadline to drop a course with a 100% refund is the end of week 2. The deadline to drop with no notation on your transcript is the end of week 3.

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity website http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the university community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the university. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the university. http://www.sfu.ca/policies/gazette/student/s10-01.html