Fall 2023 - HSCI 427 D100

Immune Responses in Health and Disease (3)

Class Number: 5339

Delivery Method: In Person

Overview

  • Course Times + Location:

    Sep 6 – Dec 5, 2023: Wed, 2:30–4:20 p.m.
    Burnaby

    Sep 6 – Dec 5, 2023: Fri, 2:30–4:20 p.m.
    Burnaby

  • Instructor:

    Mani Larijani
    mlarijan@sfu.ca
    7787827276
    Office: SSB 6146
    Office Hours: Friday after class (other times by appointment through email)
  • Prerequisites:

    MBB 326 or HSCI 326, with a minimum grade of C, or permission of the instructor.

Description

CALENDAR DESCRIPTION:

Defects in the immunologic responses to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for MBB 427 may not take this course for credit.

COURSE DETAILS:

The immune system is a complex and delicately balanced system of many sub-systems, and its action often has both good and deleterious impacts. The theme of this course will be to deconstruct the simplified one-dimensional view of the immune system as a force of protection for the good of the host, and to explore its dual roles in maintaining health but also in causing or being involved in disease. Furthermore, pathogens interact in complex ways with the immune system, often subverting it for their own gain or re-directing it to cause future health problems in the host.

COURSE-LEVEL EDUCATIONAL GOALS:

This course aims to explore the complexities and molecular/cellular mechanisms that underpin the balance between the dual roles of the immune system in health and disease. We will do so in the context of three modules:

1. Generation of receptor diversity: necessary for immunity but also a driver of cancer
2. Anti-viral factors that restrict virus replication, and their subversion by viruses and roles in cancer
3. The links between immunodeficiencies, autoimmunity and cancers

Grading

  • 2 Midterm Exams ( 35% each) 70%
  • Group presentation (team-based) 25%
  • Class discussion participation 5%

NOTES:

Exam format and Policy:
Exams will be held on the dates indicated and in the location of in-person lectures. The format of the exams will be a mix of multiple choice, short answer questions, and longer more open-ended questions (half to 1-page mini essay) designed to encourage imagination and conceptual thinking.

The exams will be in hand-written closed-book fashion, with no electronic devices permitted.

Exam attendance is mandatory. If the instructor is made aware of extenuating circumstances, i.e., illness, University sports travel, BEFORE the exam, other arrangements can be made. The manner of accommodation will be at the discretion of the instructor. It could include, but is not limited to, a make-up exam (either in-person or online) or re-weighting of existing evaluations.

Grade disputes and re-grades: If points for an exam have not been properly tabulated, please indicate this to the TA so a correction can be made (simply done as a Canvas entry). If you want a question(s) on an exam re-graded, give the exam to your TA; the TA will then bring the exam to the instructor. The instructor will then, in consultation with the TA, in an unbiased fashion, remark the ENTIRE exam. Please note that this could result in the assignment of a LOWER grade. There is a deadline of 2 weeks from the viewing of a midterm exam for requesting a re-grade.

Group presentations and class discussion:
Each presentation will be delivered by a group (3-5) students depending on class size. The groups will present a on a topic related to one of the three learning modules. The presentation should include 3-4 peer-reviewed primary data journal articles of their choosing that demonstrate the duality of the immune system: for instance, all papers can be on the complex dual nature and linkages, or 2 can be focusing on the “good” or “pro-health” roles of an immune molecule(s)/cell(s)/system(s) while 2 focus on the flip “bad” or “disease causing/exacerbating” side of the coin.

Each presentation will need to include an introduction to the topics and the broader context that are needed for understanding the article and an educational introduction to the pathogenesis of the immunological disease of interest. After that, the presentation will need to describe the research studies, focusing on the main figures/findings, and going through methodologies used to reach the conclusions. There should be a description of the study approach and key experiments and/or observations. This should be followed by a discussion of the caveats of the studies and questions for future studies, as well as a more comprehensive list of key reference papers on the topic beyond the 4 papers which could include recent review articles that the team has referred to in making up the presentation. It will be important to present material that educates the class beyond the material that is covered in the lectures, but it is encouraged to build upon this material.

Each team can divide these sections of the presentation so that team members share roughly equal time in presenting at the session.

The presentation will be followed by class discussion. 

The team will be graded on the depth of their understanding of the topic, polish/style of their presentation, and stimulation of class discussion.

Participation
A 5% mark will be assigned based on the participation in class during lectures and discussion of group presentations.

REQUIREMENTS:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS
SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of academic dishonesty. Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for their own conduct as it affects the University community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

The specific policy of this course/instructor is zero tolerance for plagiarism or non-author-original material, or any form of cheating on exams, including concealed information to which one can refer during an exam, looking at another student’s exam, opening books when not authorized. Students will be rigorously examined to ensure that all written and presented materials are the result of their own original thinking and learning.

Materials

REQUIRED READING NOTES:

Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity website http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the university community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the university. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the university. http://www.sfu.ca/policies/gazette/student/s10-01.html

RELIGIOUS ACCOMMODATION

Students with a faith background who may need accommodations during the semester are encouraged to assess their needs as soon as possible and review the Multifaith religious accommodations website. The page outlines ways they begin working toward an accommodation and ensure solutions can be reached in a timely fashion.