Simon Fraser University
Engaging the World

Course Outlines

Fall 2026 - CHEM 455 D100

Synthetic Organic Chemistry (3)

Class Number: 1708

Delivery Method: In Person

Overview

  • Course Times + Location:

    Sep 9 – Dec 7, 2026: Tue, Thu, 2:30–4:20 p.m.
    Burnaby

  • Prerequisites:

    CHEM 381 with a minimum grade of C-, or permission of the instructor.

Description

CALENDAR DESCRIPTION:

This course teaches the principles involved in the planning and execution of the synthesis of organic molecules. Emphasis is on synthesis of naturally occurring compounds of biological importance.

COURSE DETAILS:

This course teaches the principals involved in the planning and execution of the synthesis of organic molecules, and mechanistic insights into the stereocontrolled synthesis of complex molecules. Emphasis is on synthesis of naturally occurring compounds of biological importance.

COURSE-LEVEL EDUCATIONAL GOALS:

  1. Develop retrosynthetic thinking - Learn how to work backward from a target molecule to simpler starting materials. Analyze multiple possible synthetic routes to a molecule and choose efficient strategies.

 

  1. Understand modern synthetic methodology - Apply contemporary reactions, reagents, and synthetic techniques used in organic chemistry. Evaluate the strengths and limitations of different transformations.

 

  1. Plan multistep syntheses - Integrate individual organic reactions into complete synthetic sequences. Consider issues such as selectivity, protecting groups, yield, and efficiency. Understand how synthetic chemistry is used to access complex natural products.

 

  1. Apply strategic problem-solving in organic chemistry - Use mechanistic understanding and reaction knowledge to solve synthetic challenges.

Grading

  • Research Project/Presentation 25%
  • Midterm Examination 25%
  • Final Examination 50%

Materials

RECOMMENDED READING:

The Logic of Chemical Synthesis. Corey and Chang, Wiley, 1989

Classics in Total Synthesis. Nicolaou and Sorensen, VCH, 1996

Strategic Applications of Named Reactions in Organic Synthesis, Laszlo Kurti and Barbara Czako (Elsevier Academic Press)


Department Undergraduate Notes:

A grade of C- or better is required for all prerequisite courses.

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

At SFU, you are expected to act honestly and responsibly in all your academic work. Cheating, plagiarism, or any other form of academic dishonesty harms your own learning, undermines the efforts of your classmates who pursue their studies honestly, and goes against the core values of the university.

To learn more about the academic disciplinary process and relevant academic supports, visit: 


RELIGIOUS ACCOMMODATION

Students with a faith background who may need accommodations during the term are encouraged to assess their needs as soon as possible and review the Multifaith religious accommodations website. The page outlines ways they begin working toward an accommodation and ensure solutions can be reached in a timely fashion.