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Department of Molecular Biology and Biochemistry | Faculty of Science Simon Fraser University Calendar | Spring 2022

Genomics

Certificate

The Genomics Certificate Program includes 30 units, 21 of which are required with the remaining 9 selected from a list of electives.

Admission Requirements

Admission is governed by the University's admissions regulations. After University admission, approval of the Molecular Biology and Biochemistry (MBB) Program Coordinator is required for formal acceptance into the program. This may be done anytime before graduation, but is recommended upon completion of MBB 342. The certificate can be completed by students in various major programs that use the life sciences undergraduate core curriculum for the lower division requirements. Credits applied to one certificate may not be applied to another certificate or diploma.

Prerequisite and Required Course Grades

Students enrolling in upper division MBB courses must have a grade of C or better in prerequisite courses. Students enrolled in this certificate program must have a grade of C- or better in all required courses (including those selected from the list of electives) to graduate with this certificate.

Program Requirements

Students must have a minimum 2.0 grade point average (GPA) calculated on all required courses (including those selected from the list of electives).

Students must complete all of

BISC 202 - Genetics (3) *

Principles and concepts of the transmission of genetic information. Prerequisite: BISC 101 and 102 with a grade of C- or better.

Section Instructor Day/Time Location
D100 Kevin Lam
Tu 2:30 PM – 4:20 PM
Th 2:30 PM – 3:20 PM
WMC 3520, Burnaby
WMC 3520, Burnaby
D101 Tu 4:30 PM – 5:20 PM
AQ 5006, Burnaby
D102 Tu 4:30 PM – 5:20 PM
AQ 5005, Burnaby
D103 Tu 5:30 PM – 6:20 PM
AQ 5006, Burnaby
D104 Tu 5:30 PM – 6:20 PM
AQ 5005, Burnaby
D105 Th 3:30 PM – 4:20 PM
AQ 5008, Burnaby
D106 Th 3:30 PM – 4:20 PM
AQ 5007, Burnaby
D107 Th 4:30 PM – 5:20 PM
AQ 5005, Burnaby
D108 Th 4:30 PM – 5:20 PM
AQ 5008, Burnaby
D109 Fr 12:30 PM – 1:20 PM
AQ 5007, Burnaby
D110 Fr 1:30 PM – 2:20 PM
AQ 5005, Burnaby
MBB 222 - Molecular Biology and Biochemistry (3) *

The structure, function and synthesis of proteins, RNA and DNA and their interrelated biological functions within the cell. An introduction to molecular biology techniques and methods of protein purification and analysis. Prerequisite: or Corequisite CHEM 281.

Section Instructor Day/Time Location
D100 Michel Leroux
Mo, We, Fr 11:30 AM – 12:20 PM
AQ 3182, Burnaby
D101 Mo 9:30 AM – 10:20 AM
WMC 2260, Burnaby
D102 Tu 10:30 AM – 11:20 AM
WMC 2533, Burnaby
D103 Tu 12:30 PM – 1:20 PM
BLU 10901, Burnaby
D104 Tu 9:30 AM – 10:20 AM
AQ 5004, Burnaby
D105 We 3:30 PM – 4:20 PM
AQ 4120, Burnaby
D106 Fr 9:30 AM – 10:20 AM
WMC 2523, Burnaby
D107 We 8:30 AM – 9:20 AM
AQ 5007, Burnaby
D108 Mo 2:30 PM – 3:20 PM
AQ 2122, Burnaby
MBB 231 - Cellular Biology and Biochemistry (3) *

A study of the molecular processes which underlie cell structure and function, integrating ultrastructural, physiological and biochemical approaches. Modern techniques used in the analysis of organelle and cell function are integral parts of the course. Prerequisite: MBB 222, BISC 101, CHEM 281 with grades of C- or better. Corequisite or Prerequisite: CHEM 282 or CHEM 283.

Section Instructor Day/Time Location
D100 Ingrid Northwood
Mo, We 11:30 AM – 12:20 PM
Fr 11:30 AM – 12:20 PM
SSCB 9200, Burnaby
SSCB 9200, Burnaby
D101 Mo 9:30 AM – 10:20 AM
BLU 10901, Burnaby
D102 Mo 2:30 PM – 3:20 PM
WMC 2531, Burnaby
D103 Tu 10:30 AM – 11:20 AM
AQ 5009, Burnaby
D104 Tu 9:30 AM – 10:20 AM
AQ 2122, Burnaby
D105 Tu 1:30 PM – 2:20 PM
AQ 5025, Burnaby
D106 Tu 9:30 AM – 10:20 AM
WMC 2521, Burnaby
D107 We 12:30 PM – 1:20 PM
WMC 2533, Burnaby
D108 Mo 9:30 AM – 10:20 AM
AQ 5004, Burnaby
MBB 331 - Molecular Biology (4)

The study of DNA and RNA in relation to gene structure and expression: DNA replication and the regulation of gene expression in bacteria and higher organisms. Introduction to recombinant DNA and cloning theory; natural vector structures and recombinant vector construction. Prerequisite: MBB 231, and BISC 202, with a minimum grade of C.

Section Instructor Day/Time Location
D100 Stephanie Vlachos
Tu, Th 10:30 AM – 12:20 PM
SSCC 9000, Burnaby
D101 Tu 12:30 PM – 1:20 PM
AQ 4115, Burnaby
D102 Mo 9:30 AM – 10:20 AM
WMC 2533, Burnaby
D103 Tu 9:30 AM – 10:20 AM
WMC 2533, Burnaby
D104 Fr 9:30 AM – 10:20 AM
AQ 5009, Burnaby
MBB 342 - Introductory Genomics and Bioinformatics (3) *

Major topics in genomics and bioinformatics, with integrated discussion of associated ethical/legal/social issues. An overview of laboratory and computer-based methods to study genomes, and their applications. Hands-on computer lab session providing an opportunity to use and experiment with bioinformatics software and databases utilized in genomics and bioinformatics research. Prerequisite: MBB 231, BISC 202 and either MBB 243 or 3 units of CMPT or equivalent, all with a minimum grade of C. Recommended: STAT 201 (or an equivalent statistics course) or STAT 270.

Section Instructor Day/Time Location
D100 Sophie Sneddon
Tu 2:30 PM – 4:20 PM
AQ 4130, Burnaby
D101 Th 12:30 PM – 2:20 PM
SSB 6178, Burnaby
D103 Th 2:30 PM – 4:20 PM
SSB 6178, Burnaby

and one of

BISC 357 - Genetic Engineering (4)

Techniques in gene cloning and the evaluation of gene function are introduced in lectures and practiced in labs. Lab exercises include genomic DNA, RNA, and plasmid purification; PCR; various cloning techniques; and construction of novel genes. Students are introduced to additional techniques in lectures including gene editing, and genome sequencing. Prerequisite: BISC 202, MBB 222, and MBB 231, all with a grade of C- or better. Recommended: MBB 331. Students with credit for MBB 308 may not take this course for further credit.

MBB 308 - Molecular Biology Laboratory (3)

Modern molecular biological and recombinant nucleic acid methods will be covered. Examples are DNA and RNA isolation, plasmid preparation, restriction enzyme digestion, DNA cloning and polymerase chain reaction. Prerequisite: or corequisite: MBB 331 with a minimum grade of C-. Students with credit for BISC 357 may not take this course for further credit.

Section Instructor Day/Time Location
D100 Stephanie Vlachos
Timothy Audas
Mo 2:30 PM – 4:20 PM
AQ 3003, Burnaby
D101 Tu 1:30 PM – 5:20 PM
SSB 8158, Burnaby
D102 We 1:30 PM – 5:20 PM
SSB 8158, Burnaby
D103 Th 1:30 PM – 5:20 PM
SSB 8158, Burnaby

and one of

STAT 201 - Statistics for the Life Sciences (3)

Research methodology and associated statistical analysis techniques for students with training in the life sciences. Intended to be particularly accessible to students who are not specializing in Statistics. Prerequisite: Recommended: 30 units. Students cannot obtain credit for STAT 201 if they already have credit for - or are taking concurrently - STAT 101, 203, 205, 285, or any upper division STAT course. Quantitative.

Section Instructor Day/Time Location
D900 Wei Lin
Mo 12:30 PM – 1:20 PM
Th 12:30 PM – 2:20 PM
SRYC 2600, Surrey
SRYC 2600, Surrey
OL01 Tim Swartz
TBD
OP09 TBD
STAT 270 - Introduction to Probability and Statistics (3) *

Basic laws of probability, sample distributions. Introduction to statistical inference and applications. Prerequisite: or Corequisite: MATH 152 or 155 or 158, with a minimum grade of C-. Students wishing an intuitive appreciation of a broad range of statistical strategies may wish to take STAT 100 first. Quantitative.

Section Instructor Day/Time Location
D100 Derek Bingham
Mo, We, Fr 9:30 AM – 10:20 AM
WMC 3520, Burnaby
D900 Wei Lin
Mo 2:30 PM – 4:20 PM
We 2:30 PM – 3:20 PM
SRYC 3310, Surrey
SRYC 3310, Surrey
OL01 Tim Swartz
TBD
OP01 TBD
OP09 TBD

and three of

BISC 424 - Applied Genomics (3)

The course provides an overview of "omics" methods in large-scale identification of gene functions in various organisms, and demonstrates how this knowledge can be applied in genomics fields, including plant and animal breeding. Prerequisite: BISC 101, BISC 102, BISC 202, MBB 222, MBB 231, and either BISC 357 or MBB 331; all with a grade of C- or better. Students who have taken Special Topics BISC 471 Applied Genomics may not take this course for further credit.

Section Instructor Day/Time Location
D100 Jim Mattsson
Mo 11:30 AM – 12:20 PM
We 11:30 AM – 12:20 PM
Fr 11:30 AM – 12:20 PM
BLU 10021, Burnaby
BLU 10021, Burnaby
AQ 5016, Burnaby
D101 Mo 1:30 PM – 2:20 PM
AQ 5007, Burnaby
D102 Mo 2:30 PM – 3:20 PM
AQ 5007, Burnaby
BISC 471 - Special Topics in Cells, Molecules and Physiology (3) #

Special Topics in Cells, Molecules and Physiology not currently offered in the Department of Biological Science. Prerequisite: To be announced.

BISC 472 - Special Topics in Cells, Molecules and Physiology (3) #

Selected topics in areas not currently offered within the undergraduate course offerings in the Department of Biological Sciences. Prerequisite: To be announced.

BISC 473 - Special Topics in Ecology, Evolution and Conservation (3) #

Selected topics in Ecology, Evolution and Conservation not currently offered in the Department of Biological Science. Prerequisite: To be announced.

MBB 343 - Data Science Laboratory for Molecular Biology and Biochemistry (2) +

Hands-on application of modern tools and methods for data acquisition, management, visualization, and machine learning, capable of scaling to Big Data. No prior computer programming experience required. Examples will draw from the life sciences. Prerequisite: MBB 222 and one of STAT 201, STAT 203, STAT 205, or STAT 270 with a minimum grade of C- or permission of the instructor. Corequisite: STAT 320. Students who have taken STAT 240, STAT 310, or STAT 440 first may not then take this course for further credit. Quantitative.

MBB 420 - Selected Topics in Contemporary Biochemistry (3) #

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: Will be announced before the start of the term and will depend upon the nature of the topic offered.

MBB 440 - Selected Topics in Contemporary Molecular Biology (3) #

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: will depend upon the nature of the topic offered.

MBB 441 - Bioinformatics (3)

Examining the use of, and theory behind, bioinformatic software and algorithms for the analysis of macromolecular data. Includes consideration of recent literature and discussion of ethics in method development and analysis. Prerequisite: MBB 243 or 3 units of CMPT or equivalent with a minimum grade of C, or permission of the instructor; MBB 331 and MBB 342, with a minimum grade of C.

Section Instructor Day/Time Location
D100 Sophie Sneddon
Tu, Th 4:30 PM – 6:20 PM
AQ 3149, Burnaby
MBB 460 - Selected Topics in Bioinformatics and Genomics (3)

The topics in this course will vary from term to term, depending on faculty availability and student interest. Students may repeat this course for further credit under a different topic. Prerequisite: Will vary depending on the topic.

MBB 461 - Comparative Genomics (3)

Examination of the fundamentals of comparative genomics, identification and activity of functional elements in genomes, inter- and intra-species comparisons, relationship of genomic to phenotypic variation, and personalized genomics are among the topics to be explored. Comparison of genome data has impacts on medicine and many other fields of the life sciences. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students who have completed MBB 440 Comparative Genomics may not complete this course for further credit.

MBB 462 - Human Genomics (3)

The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students with credit for MBB 440 with this same course title may not complete this course for further credit.

Section Instructor Day/Time Location
D100 Robert Holt
We, Fr 12:30 PM – 2:20 PM
RCB 8100, Burnaby
MBB 463 - Forensic Genomics (3)

A focus on the molecular and genomic biology associated with forensic science, including genome structure, genotyping, genetic analysis of DNA fingerprints, DNA data bases and CODIS, Y STRs. mtDNA and ethical considerations of DNA typing. Prerequisite: MBB 331, with a minimum grade of C.

MBB 464 - From Genome to System (3)

Methods that enable the integration of Biochemical, Genetic and Genomic knowledge (BiGG) to reconstruct a genomic scale network that defines the metabolic physiology of an organism will be explored. Applications of these approaches in the fields of microbial evolution, interaction networks, genetic engineering and drug discovery will be discussed. Prerequisite: MBB 331 and MBB 342.

Section Instructor Day/Time Location
D100 Frederic Pio
We 8:30 AM – 10:20 AM
Fr 8:30 AM – 10:20 AM
SSB 6178, Burnaby
SSB 6178, Burnaby

# course must be in an area related to genomics and must be approved by the MBB academic advisor

* courses require additional prerequisites

+ STAT 320-2 (Introduction to Data Science for the Life Sciences) must be taken concurrently with MBB 343; these courses together count as one of the three