Welcome to the website of Prof. Mario Pinto's research group, members of the Simon Fraser University Chemistry department and its Glycoscience Research Division. We are actively engaged in multidisciplinarity studies in a wide variety of carbohydrate-related areas of chemistry and biochemistry, using a diverse set of tools and approaches. Our current interests are summarized below, along with representative active-site crystal structures and MD snapshots demonstrating a variety of our activities. Further details are available elsewhere on this site.

Thank you for your visit.



Current Interests in Brief

a) Investigation of the nature and origin of conformational effects.

b) Synthesis and conformational analysis of oligosaccharide antigenic determinants.

c) Molecular recognition in antibody-antigen interaction.

d) Development of immunodiagnostic reagents and vaccines employing carbohydrate antigens.

e) Design of glycosylation inhibitors for control of microbial infections and chronic mammalian conditions, e.g. cancer, type-2 diabetes.

f) Interaction between transition-state- and non-hydrolyzable substrate analogues and carbohydrases

g) Synthesis, conformational analysis, and reactions of organosulfur and organoselenium compounds.

h) Discovery of peptide mimics of oligosaccharide epitopes for immunodiagnostics, vaccines, and therapeutics

i) Transferred-NOE/STD NMR spectroscopy.

  • Bound conformations of ligands by combined NMR/Molecular dynamics protocols.
  • Structure and dynamics of oligosaccharides.
  • Synthetic methods in carbohydrate chemistry.
  • Nucleoside and nucleotide analogues as antiviral agents.
  • Nucleotide analogues as gene-silencing agents.
  • Control of glycoprotein trafficking in cells.
  • Development of analytical methods for glycan profiling.
  • Modulation of convertase activity in cells.
  • Modulation of UDP-Galp mutase activity in M. tuberculosis.
  • Modulation of intestinal glucosidase activities for control of obesity and type-2 diabetes.

The Octapeptide MDWMHAA Bound to Shigella Flexneri Y Antibody SYAJ6

Kotalanol Complexed With Alpha Glucosidases

UDP-Galactofuranose Mutase with Natural Substrate

Influenza Neuraminidase Complexed with our Inhibitors