Scott Lab at Simon Fraser University

Naveed Gulzar, Research Associate

(Spring 2009 - present)
Ph.D. 2008 Microbiology and Immunology, University of Ottawa
B.Sc. 2001 (Biochemistry - honours), University of Ottawa

Email:  ngulzar@sfu.ca

Current Projects

My research experience lies at the intersection of molecular virology and immunology, studying the complex interplay between host immune responses and viral pathogenesis in chronic infections (i.e. HIV, HCV). During my doctoral research, I identified a new cellular target of HIV in late-stage infection (Gulzar et al., Current HIV Research, 2008; 6(6): 585-596; Gulzar et al., Open AIDS Journal, 2008; 2: 43-57). In my post-doctoral research, I characterized a novel DNA vaccine that targeted a conserved epitope within the HIV envelope protein, and designed immunization strategies to elicit neutralizing antibodies against it (Montero and Gulzar, et al., Journal of Virology, 2012; 86(6):2930-41).

My current and future research interests pertain to examining the development of the neutralizing antibody response in HIV/HCV co-infected individuals. Such studies will have a profound impact upon the development of preventative and therapeutic strategies to manage chronic viral diseases; a lack of understanding of the host immune response in a co-infection setting has hampered our ability to successfully develop treatment strategies.

Awards

MSFHR Post Doctoral Fellowship Award, 2011-2013

Select Publications

  1. Montero, M., Gulzar, N.*, Klaric, K., Donald, J., Lepik, C., Wu, S., Tsai, S., Julien, J., Hessell, A., Wang, S., Lu, S., Burton, R., Pai, E., DeGrado, W., and Scott, J. K. Neutralizing Epitopes in the MPER of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane.  (2012). J. Virol. [ePub]. (*co-first author; co-corresponding author).
  2. Gulzar, N., Balasubramanian, S., Diker, B., Jiang, J., and Copeland, K.  F. HIV-1 Infection Protects Against a Tc1 to Tc2 Shift in CD8+ T-cells.  (2011). Human Immunology. 72(11): 995-1000.
  3. Romanuik, S. F., Grist, S. M., Gray, B. L., Hohertz, D., Kavanagh, K., Gulzar, N., Scott, J. K., Nirwan, R., Hui, C., Brolo, A. G., and Gordon, R. Detecting antibodies secreted by trapped cells using extraordinary optical transmission.  (2011). IEEE Sensors. 11(11): 2732 – 2739.
  4. Romanuik, S. F., Grist, S. M., Haq, M., Gray, B. L., Gulzar, N., Scott, J. K., Hohertz, D., Kavanagh, K. L., Nirwan, R., Hui, C., Brolo, A. G., Gordon, R. Microfluidic trapping of antibody-secreting cells. Journal of Medical and Biological Engineering. (2011). 31(2): 121-127.
  5. Gulzar, N., Shroff, A., Buberoglu, B., Klonowska, D., Kim, J.  E., and Copeland, K.  F. Properties of HTLV-I Transformed CD8+ T-Cells in Response to HIV-1 Infection. Virology. (2010). 406(2): 302-311.
  6. Gulzar, N., Diker, B., Mihowich J., Deschatelets, J.,Arsenault M.  E., Lamoureux, N., Cameron, W.  D., Kim, J.  K., Copeland, K.  F.  T.  Proportion of HIV-1 Infected CD8+CD4- T Lymphocytes in vivo.  Current HIV Research.  (2008). 6(6): 585-596.
  7. Gulzar, N., Balasubramanian, S., Harris, G., Sanchez-Dardon, J., and Copeland, K.  F.  Infection of CD8+CD45RO+ Memory T-cells by HIV-1 and Their Proliferative Response.  Open AIDS Journal.  (2008). 2: 43-57.
  8. Gulzar, N., and Copeland, K.  F.  CD8+ T-Cells:  Function and Response to HIV Infection.  Current HIV Research.  (2004). 2(1): 23-37.
  9. Haddad, A., Nokhbeh, M.  R., Alexander, D.  A., Dawe, S.  J., Grisé, C., Gulzar, N., and Dimock, K.  Binding to Decay-Accelerating Factor Is Not Required for Infection of Human Leukocyte Cell Lines by Enterovirus 70.  J. Virology.  (2004). 78: 2674-2681.

Other Publications

  1. Brolo, A.G., Scott, J.K., Gray, B. L.,  Kavanagh, K. L.,  Gordon, R, Gulzar, N., Hohertz, D., Romanuik, S. F., Grist, S. M., and Nirwan, R. A new method for therapeutic antibody screening. SPIE Newsroom, 1-3. DOI: 10.1117/2.1201006.002995. Posted online: July 6 2010.