Scott Lab at Simon Fraser University

Publications, Posters and Presentations

Publications

  1. Watson, C.T., Steinberg, K.M., Huddleston, J., Warren, R.L., Malig, M., Schein, J., Willsey, A.J., Joy, J.B., Scott, J.K., Graves, T., Wilson, R.K., Holt, R.A., Eichler, E.E., and Breden, F.  2013.  Complete Haplotype of the Human Immunoglobulin Heavy Variable IGHV genes from a Single Individual and Characterization of Allelic and Copy Number Variation from Haplotype Sequence Analysis.  Am J Hum Genet. 92(4): 530-46.
  2. Scott, J.K., Pantophlet, R., Craig, L. 2012.  Complex Binding Sites Made to Order. Nature Biotechnol.  (News and Views.)  30(2): 154-155.
  3. Montero, M., Gulzar, N., Klaric, K.A., Donald, J., Lepik, C., Wu, S., Tsai, S., Julien, J.P., Hessell, A., Wang, S., Lu, S., Burton, D., Pai, E., DeGrado, W., and Scott, J.K. 2012.  Neutralizing Epitopes in the MPER of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane.  J. Virol.  86(6): 2930-2941.
  4. Raymond-Bouchard, I., Carroll, C.S., Nesbitt, J.R., Henry, K.A., Pinto, L.J., Moinzadeh, M., Scott, J.K ., Moore, M.M.  2012.  The MIRB Ferrisiderophore Transporter of Aspergillus fumigatus: Structural Requirements for Activity.  Eukaryot Cell.  11(11): 1333-1344.
  5. Singh, H., Henry, K.A., Wu, S.S.T., Chruscinskia, A., Utz, P.J., and Scott, J.K.  2011.
    Reactivity Profiles of Broadly Neutralizing Anti-HIV-1 Antibodies Are Distinct from Those of Pathogenic Autoantibodies.  AIDS.  25(10): 1247-1257.
  6. Henry, K.A., Murira, A., van Houten, N.E., Scott, J.K.  2011.  Developing Strategies to Enhance and Focus Humoral Immune Responses Using Filamentous Phage as a Model Antigen.  Bioeng Bugs.  2(5): 275-283.
  7. Romanuik, S.F., Grist, S.M., Gray, B.L., Hohertz, D., Kavanagh, K., Gulzar, N., Scott, J.K., Nirwan, R., Hui, C., Brolo, A.G. and Gordon, R.  2011.  Detecting Antibodies Secreted by Trapped Cells Using Extraordinary Optical Transmission.  IEEE Sensors.  11(11): 2732-2739.
  8. Romanuik, S.F., Grist, S.M., Haq, M., Gray, B.L., Gulzar, N., Scott, J.K., Hohertz, D., Kavanagh, K.L, Nirwan, R., Hui, C, Brolo, A.G. and Gordon, R.  2011.  Microfluidic Trapping of Antibody-secreting Cells.  J. Med. & Biol. Eng.  31(2): 121-127.
  9. Zhu, Z., Qin, H.R., Chen, W., Zhao, Q., Shen, X., Schutte, R., Wang, Y., Ofek, G., Streaker, E., Prabakaranm, P., Fouda, G.G., Liao, H.X., Owens, J., Louder, M., Yang, Y., Klaric, K.A., Moody, M.A., Mascola, J.R., Scott, J.K., Kwong, P.D., Montefiori, D., Haynes, B.F., Tomaras, G.D., Dimitrov, D.S.  2011.  Cross-reactive HIV-1-neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-like Antibodies.  J Virol.  85(21): 11401-11408.
  10. Romanuik, S.F., Grist, S.M., Gray, B.L., Hohertz, D., Kavanagh, K., Gulzar, N., Scott, J.K., Nirwan, R., Hui, C., Brolo, A.G., and Gordon, R.  2010.  Sensing of Antibodies Secreted by Microfluidically Trapped Cells via Extraordinary Optical Transmission through Nanohole Arrays.  IEEE Sensors, 2105-2108.
  11. Breden, F., Lepik, C., Longo, N.S., Montero, M., Lipsky, P.E., Scott, J.K.  2010.  Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease.  PLoS ONE   6(3): e16857.
  12. Irving, M.B., Craig, L., Menendez, A., van Houten, N.E., Montero, M. and Scott, J.K.  2010.  Exploring Peptide Mimics for the Production of Antibodies against Discontinuous Protein Epitopes.  Molec. Immunol.  47(5): 1137-1148.
  13. van Houten, N.E., Henry, K.A., Smith, G.P. and Scott, J.K.  2010.  Engineering Filamentous Phage as a Carrier to Focus Antibody Responses against a Peptide.  Vaccine  28(10): 2174-2185.
  14. Feldman, A.R., Shapova, Y.A., Wu, S.S.T., Oliver, D.C., Heller, M., McIntosh, L.P., Scott, J.K. and Paetzel, M.  2008.  Phage Display and Crystallographic Analysis Reveals Potential Substrate/Binding Site Interactions in the Protein Secretion Chaperone CsaA from Agrobacterium tumefaciens.  J. Mol. Biol.  379(3): 457-470.
  15. Menendez, A.*, Calarese, D.*, Stanfield, R.L.*, Chow, K.C., Scanlon, C., Kunert, R., Katinger, H., Burton, D.R., Wilson, I.A. and Scott, J.K. ¶  2008.  A Peptide Inhibitor of HIV-1 Neutralizing Antibody 2G12 Is Not a Structural Mimic of the Natural Carbohydrate Epitope on gp120.  FASEB J.  22: 1380-1392.  *These authors contributed equally to this work.  Co-corresponding authors.
  16. Montero, M. *, van Houten, N.E. *, Wang, X. and Scott, J.K.  2008.  The Membrane Proximal External Region of the HIV-1 Envelope: A Dominant Site of Antibody Neutralization and Target for Vaccine Design.  Microbiol. Mol. Biol. Rev. 72(1): 54-84.  *These authors contributed equally to this work.

Posters and Presentations

Underline is presenter, italics is lab member.

  1. Murira, A., Henry, K.A., Ahmed,F.K., and Scott, J.K. Transcriptomic profiling of CD138+ cells from immunized mice indicates ontological heterogeneity. ImmunoBC 2015. Vancouver, BC. 11 June 2015.
  2. Marthandan, N., Henry, K.A., Murira, A.M., Nickel, K., Ahmed, F., Breden,F.J., and Scott, J.K. B receptor repertoire analysis to study antibody responses elicited by hyperimmunization with a bacteriophage. ImmunoBC 2015. Vancouver, BC. 11 June 2015.
  3. Gulzar, N., Ahmed, F.K., Rujas, E., Apellaniz, B., McCully, M.E., Wang,S., DeGrado, W.F., Nieva, J.L., Lu, S., and Scott, J.K. Durable Antibody Responses Against the 2F5 Region of the MPER of HIV gp41 are Elicited using Engineered DNA and Liposome Vaccines, and Co-Immunization Strategies. ImmunoBC 2015. Vancouver, BC. 11 June 2015.
  4. Breden, F., Marthandan, N., Zimonja, B., Jaglale,J., Scott,J.K., and Brian Corrie. iReceptor: Bioinformatic Platform for Storing and Sharing Next Generation Sequencing (NGS) Data from Immune Repetoires. ImmunoBC 2015. Vancouver, BC. 11 June 2015.
  5. Murira, A., and Scott, J.K. Transcriptomic profiling of CD138+ cells from immunized mice indicates ontological heterogeneity. Keystone Symposia: The Golden Anniversary of B Cell Discovery. Banff, Alberta. 22-27 March 2015.
  6. Henry, K.A., Murira, A.M., Marthandan, N., Nickel, K., Ahmed, F., Breden, F.J., and Scott,J.K. Immune profiling of IgM and IgG antibody response elicited by hyperimmunization with a virus-like particle. Keystone Symposia: The Golden Anniversary of B Cell Discovery. Banff, Alberta. 22-27 March 2015.
  7. Ahmed, F.K., Gulzar, N., Apellaniz, B., Rujas, E., McCullly, M.E., Hannigan, B., Ulas, G., Wang, S., and Scott, J.K. Immunization Strategies for Engineering DNA and Liposome Vaccines that Target the MPER of HIV gp41. Keystone Symposia: HIV Vaccines. Banff, Alberta. 22-27 March 2015.
  8. Murira, A., Henry, K.A., Nickel, K., and Scott, J.K. Murine B-cell Responses during Hyperimmunization with a Virus-like Particle. Antibody Engineering and Therapeutics. Huntington Beach, CA. 8-12 December 2013.
  9. Gulzar, N., McCully, M.E., Parfyonov, M., Klaric, K.A., Hannigan, B.T., Ulas, G., DeGrado, W.F., and Scott, J.K. Study 2: DNA Vaccines Expressing the Membrane Proximal External Region of HIV-1 gp41 to Optimize Exposure of Neutralizing Epitopes. AIDS Vaccine 2013. Barcelona, Spain. 6 October 2013.
  10. Gulzar, N., Ahmed, F., Rujas, E., Apellaniz, B., Klaric, K.A., Parfyonov, M., Huerte, N., Montero, M., Nieva, J., Lu, S., and Scott, J.K. Study 1: A DNA-prime, Liposome-boost Immunization Strategy Targeting the 2F5 Epitope of the Membrane Proximal External Region of HIV-1 gp41. AIDS Vaccine 2013. Barcelona, Spain. 6 October 2013.
  11. Gulzar, N., Klaric, K.A., Parfyonov , M., Montero, M., Wang, S., Huarte, N., Appellaniz, B., Nieva, J., Lu, S., and Scott, J.K. Study 1: Optimizing DNA Vaccines that Target the 2F5 Epitope of the Membrane Proximal External Region of HIV-1 gp41. AIDS Vaccine 2013. Barcelona, Spain. 6-11 October 2013.
  12. Gulzar, N., Klaric, K.A., Parfyonov, M., Montero, M., Hannigan, B., McCully, M., Ulas, G., Wang, S., Huarte, N., Appellaniz, B., Nieva, J., Lu, S., DeGrado, W.F., and Scott, J.K. DNA Vaccines that Optimally Present Neutralizing Epitopes within the Membrane Proximal External Region of HIV-1 gp41. ImmunoVancouver 2013. Vancouver, Canada. 13 June 2013.
  13. Bailey, J.J., Henry, K.A., Scott, J.K., and Bundle, D.R. An HIV-1 Glycoconjugate Vaccine Utlilizing Filamentous Phage as an Immunogenic Carrier. 9th Annual National Carbohydrate Symposium. Banff, Alberta. 8-10 May 2013.
  14. Gulzar, N., Klaric, K.A., Parfyonov, M., Montero, M., Hannigan, B., McCully, M., Ulas, G., Wang, S., Huarte, N., Appellaniz, B., Nieva, J., Lu, S., DeGrado, W.F., and Scott, J.K. DNA Vaccines that Optimally Present Neutralizing Epitopes within the Membrane Proximal External Region of HIV-1 gp41. Canadian Association for AIDS/HIV Research, 22nd Annual Meeting. Vancouver, Canada. 10 April 2013.
  15. Henry, K.A., Murira , A., Joy,J.B., Aghaeepour, N., Chen, W., Prabakaran, P., Dimatrov, D.S., Brinkman, R.R., Breden, F., and Scott, J.K. Tools for characterizing phenotypic and immunogenetics features of the B-cell response against HIV. Canadian Society for Immunology 2013. Whistler, BC. 5-8 April 2013.
  16. Bailey, J.J., Reiz, B., Henry, K.A., Scott, J.K., and Bundle, D.R. HIV-1 glycoconjugate vaccine utilizing filamentous bacteriophage as an immunogenic carrier. Canadian Society for Immunology 2013. Whistler, BC. 5 April 2013.
  17. Murira , A., Henry, K.A., and Scott, J.K. Murine B-cell responses during hyperimmunization with a virus-like particle. Canadian Society for Immunology 2013. Whistler, BC. 5-8 April 2013.
  18. Henry, K.A., Wang, X., Wang, C., Wu, S.S.T., Kingsley, L., Rinaldo, C.R. Jr, Richman, D.D., Silverman, G.J., and Scott, J.K. Serological profiling of antibody responses during HIV infection. Keystone Symposium on B cell Development (X1) and HIV Vaccines (X2). Keystone, CO, USA. 10-15 Feb 2013.
  19. Murira, A., Henry, K.A., Aghaeepour, N., Brinkman, R.R., Moir, S., and Scott, J.K. A systems immunology approach to investigate the antibody response during HIV infection. Keystone Symposium on B cell Development (X1) and HIV Vaccines (X2). Keystone, CO, USA. 10-15 Feb 2013.
  20. Murira, A., Henry, K.A., and Scott, J.K. Murine B-cell Responses during Hyperimmunization with a Virus-like Particle. Keystone Symposium on B cell Development (X1) and HIV Vaccines (X2). Keystone, CO, USA. 10-15 Feb 2013.