Example 37.2: Life Table Estimates for Males with Angina Pectoris
The data in this example come from Lee (1992, p. 91) and
represent the survival rate of males with angina pectoris.
Survival time is measured as years from the time of diagnosis.
The data are read as number of events and
number of withdrawals in each one-year time interval for 16 intervals.
Three variables are constructed from the data: Years (an artificial
time variable with values that are the midpoints of the time intervals),
Censored (a censoring indicator variable with value 1
indicating censored
observations and value 0 indicating event observations), and
Freq (the
frequency variable).
Two observations are created for
each interval, one representing the event observations
and the other representing the censored observations.
title 'Survival of Males with Angina Pectoris';
data males;
keep Freq Years Censored;
retain Years -.5;
input fail withdraw @@;
Years + 1;
Censored=0;
Freq=fail;
output;
Censored=1;
Freq=withdraw;
output;
datalines;
456 0 226 39 152 22 171 23 135 24 125 107
83 133 74 102 51 68 42 64 43 45 34 53
18 33 9 27 6 23 0 30
;
PROC LIFETEST is invoked to compute the various life table
survival estimates, the median residual time, and their standard errors.
The life table method of computing estimates is requested by specifying
METHOD=LT. The intervals are specified by the INTERVAL= option.
Graphs of the life table estimate, log of the estimate,
negative log-log of the estimate, estimated density function, and estimated
hazard function are requested by the PLOTS= option.
No tests for homogeneity are carried
out because the data are not stratified.
symbol1 c=blue;
proc lifetest data=males method=lt intervals=(0 to 15 by 1)
plots=(s,ls,lls,h,p);
time Years*Censored(1);
freq Freq;
run;
Output 37.2.1: Life Table Survival Estimates
Survival of Males with Angina Pectoris |
Life Table Survival Estimates |
Interval |
Number Failed |
Number Censored |
Effective Sample Size |
Conditional Probability of Failure |
Conditional Probability Standard Error |
Survival |
Failure |
Survival Standard Error |
Median Residual Lifetime |
Median Standard Error |
Evaluated at the Midpoint of the Interval |
[Lower, |
Upper) |
PDF |
PDF Standard Error |
Hazard |
Hazard Standard Error |
0 |
1 |
456 |
0 |
2418.0 |
0.1886 |
0.00796 |
1.0000 |
0 |
0 |
5.3313 |
0.1749 |
0.1886 |
0.00796 |
0.208219 |
0.009698 |
1 |
2 |
226 |
39 |
1942.5 |
0.1163 |
0.00728 |
0.8114 |
0.1886 |
0.00796 |
6.2499 |
0.2001 |
0.0944 |
0.00598 |
0.123531 |
0.008201 |
2 |
3 |
152 |
22 |
1686.0 |
0.0902 |
0.00698 |
0.7170 |
0.2830 |
0.00918 |
6.3432 |
0.2361 |
0.0646 |
0.00507 |
0.09441 |
0.007649 |
3 |
4 |
171 |
23 |
1511.5 |
0.1131 |
0.00815 |
0.6524 |
0.3476 |
0.00973 |
6.2262 |
0.2361 |
0.0738 |
0.00543 |
0.119916 |
0.009154 |
4 |
5 |
135 |
24 |
1317.0 |
0.1025 |
0.00836 |
0.5786 |
0.4214 |
0.0101 |
6.2185 |
0.1853 |
0.0593 |
0.00495 |
0.108043 |
0.009285 |
5 |
6 |
125 |
107 |
1116.5 |
0.1120 |
0.00944 |
0.5193 |
0.4807 |
0.0103 |
5.9077 |
0.1806 |
0.0581 |
0.00503 |
0.118596 |
0.010589 |
6 |
7 |
83 |
133 |
871.5 |
0.0952 |
0.00994 |
0.4611 |
0.5389 |
0.0104 |
5.5962 |
0.1855 |
0.0439 |
0.00469 |
0.1 |
0.010963 |
7 |
8 |
74 |
102 |
671.0 |
0.1103 |
0.0121 |
0.4172 |
0.5828 |
0.0105 |
5.1671 |
0.2713 |
0.0460 |
0.00518 |
0.116719 |
0.013545 |
8 |
9 |
51 |
68 |
512.0 |
0.0996 |
0.0132 |
0.3712 |
0.6288 |
0.0106 |
4.9421 |
0.2763 |
0.0370 |
0.00502 |
0.10483 |
0.014659 |
9 |
10 |
42 |
64 |
395.0 |
0.1063 |
0.0155 |
0.3342 |
0.6658 |
0.0107 |
4.8258 |
0.4141 |
0.0355 |
0.00531 |
0.112299 |
0.017301 |
10 |
11 |
43 |
45 |
298.5 |
0.1441 |
0.0203 |
0.2987 |
0.7013 |
0.0109 |
4.6888 |
0.4183 |
0.0430 |
0.00627 |
0.155235 |
0.023602 |
11 |
12 |
34 |
53 |
206.5 |
0.1646 |
0.0258 |
0.2557 |
0.7443 |
0.0111 |
. |
. |
0.0421 |
0.00685 |
0.17942 |
0.030646 |
12 |
13 |
18 |
33 |
129.5 |
0.1390 |
0.0304 |
0.2136 |
0.7864 |
0.0114 |
. |
. |
0.0297 |
0.00668 |
0.149378 |
0.03511 |
13 |
14 |
9 |
27 |
81.5 |
0.1104 |
0.0347 |
0.1839 |
0.8161 |
0.0118 |
. |
. |
0.0203 |
0.00651 |
0.116883 |
0.038894 |
14 |
15 |
6 |
23 |
47.5 |
0.1263 |
0.0482 |
0.1636 |
0.8364 |
0.0123 |
. |
. |
0.0207 |
0.00804 |
0.134831 |
0.054919 |
15 |
. |
0 |
30 |
15.0 |
0 |
0 |
0.1429 |
0.8571 |
0.0133 |
. |
. |
. |
. |
. |
. |
|
Results of the life table estimation are shown in Output 37.2.1.
The five-year survival rate is 0.5193 with a standard error of 0.0103.
The estimated
median residual lifetime, which is 5.33 years initially, has reached
a maximum of 6.34 years at the beginning of the second year and decreases
gradually to a value lower than the initial 5.33 years at the beginning of
the seventh year.
Output 37.2.2: Summary of Censored and Event Observations
Summary of the Number of Censored and Uncensored Values |
Total |
Failed |
Censored |
Percent Censored |
2418 |
1625 |
793 |
32.80 |
NOTE: |
There were 2 observations with missing values, negative time values or frequency values less than 1. |
|
|
Output 37.2.2 shows the number of event and censored observations.
The percentage of the patients
that have withdrawn from the study is 32.8%.
Output 37.2.3: Life Table Survivor Function Estimate
Output 37.2.4: Log of Survivor Function Estimate
Output 37.2.5: Log of Negative Log of Survivor Function Estimate
Output 37.2.6: Hazard Function Estimate
Output 37.2.7: Density Function Estimate
Output 37.2.3 displays the graph of the life table survivor function
estimates versus years after diagnosis. The median survival time,
read from the survivor function curve, is
5.33 years, and the 25th and 75th percentiles are 1.04 and 11.13 years,
respectively.
As discussed in Lee (1992), the graph of the estimated hazard function
(Output 37.2.6) shows
that the death rate is highest in the first year of diagnosis. From
the end of the first year to the end of the tenth year, the death
rate remains relatively constant, fluctuating between 0.09 and 0.12.
The death rate is generally higher after the tenth year.
This could indicate
that a patient who has survived the first year has a
better chance than a patient who has just been diagnosed. The profile of
the median residual lifetimes also supports this interpretation.
An exponential model may be appropriate for the survival of these male
patients with angina pectoris since
the curve of the log of the survivor function estimate versus years of
diagnosis
(Output 37.2.4) approximates a straight line through the origin.
Visually,
the density estimate (Output 37.2.7) resembles that of an exponential
distribution.
Copyright © 1999 by SAS Institute Inc., Cary, NC, USA. All rights reserved.