Selected papers

Here is a non-exhaustive list of representative reviews on cilia and ciliopathies, research articles dealing with uncovering ciliary genomes/proteomes, and other key papers in the field of cilia research. Updated Dec. 24, 2007.

Review articles on cilia, ciliopathies

Blacque OE, Leroux MR
Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport. Cell Mol Life Sci. 2006 Sep;63(18):2145-61.

Torres VE, Harris PC.
Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases. Nat Clin Pract Nephrol. 2006 Jan;2(1):40-55.

Satir P, Christensen ST.
Overview of structure and function of mammalian cilia. Annu Rev Physiol. 2007;69:377-400.

Bisgrove BW, Yost HJ.
The roles of cilia in developmental disorders and disease. Development. 2006 Nov;133(21):4131-43. Epub 2006 Oct 4.

Zariwala MA, Knowles MR, Omran H.
Genetic defects in ciliary structure and function. Annu Rev Physiol. 2007;69:423-50.

Reiter JF, Mostov K.
Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18383-4.

Christensen ST, Pedersen LB, Schneider L, Satir P.
Sensory cilia and integration of signal transduction in human health and disease. Traffic. 2007 Feb;8(2):97-109.

Tobin JL, Beales PL.
Bardet-Biedl syndrome: beyond the cilium. Pediatr Nephrol. 2007 Jul;22(7):926-36.

Eggenschwiler JT, Anderson KV.
Cilia and developmental signaling. Annu Rev Cell Dev Biol. 2007;23:345-73.

Leroux MR.
Taking vesicular transport to the cilium. Cell. 2007 Jun 15;129(6):1041-3.

Pan J, Snell W.
The primary cilium: keeper of the key to cell division. Cell. 2007 Jun 29;129(7):1255-7.

Adams NA, Awadein A, Toma HS.
The retinal ciliopathies. Ophthalmic Genet. 2007 Sep;28(3):113-25.

Fliegauf M, Benzing T, Omran H.
When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol. 2007 Nov;8(11):880-93.

Mitchell DR
The evolution of eukaryotic cilia and flagella as motile and sensory organelles. Adv Exp Med Biol. 2007;607:130-40.

Blacque OE, Cevik S, Kaplan OI.
Intraflagellar transport: from molecular characterisation to mechanism. Front Biosci. 2008 Jan 1;13:2633-52.

Inglis PN, Ou G, Leroux MR, Scholey JM.
The sensory cilia of Caenorhabditis elegans. WormBook. 2007 Mar 8;:1-22.

Marshall WF, Nonaka S.
Cilia: tuning in to the cell's antenna. Curr Biol. 2006 Aug 8;16(15):R604-14.

Singla V, Reiter JF.
The primary cilium as the cell's antenna: signaling at a sensory organelle. Science. 2006 Aug 4;313(5787):629-33.

Inglis PN, Boroevich KA, Leroux MR.
Piecing together a ciliome. Trends Genet. 2006 Jul 20; [Epub ahead of print]

Davis EE, Brueckner M, Katsanis N.
The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle. Dev Cell. 2006 Jul;11(1):9-19.

Badano JL, Mitsuma N, Beales PL, Katsanis N.
The Ciliopathies: An Emerging Class of Human Genetic Disorders. Annu Rev Genomics Hum Genet. 2006 May 24; [Epub ahead of print]

Scholey JM, Anderson KV.
Intraflagellar transport and cilium-based signaling. Cell 2006 May 5;125(3):439-42.

Hirokawa N, Tanaka Y, Okada Y, Takeda S.
Nodal flow and the generation of left-right asymmetry. Cell 2006 Apr 7;125(1):33-45.

Benzing T, Walz G.
Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypertens. 2006 May;15(3):245-9.

Fliegauf M, Omran H.
Novel tools to unravel molecular mechanisms in cilia-related disorders. Trends Genet. 2006 May;22(5):241-5.

Hildebrandt F, Otto E.
Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease? Nat Rev Genet. 2005 Dec;6(12):928-40.

Tahvanainen E, Tahvanainen P, Kaariainen H, Hockerstedt K.
Polycystic liver and kidney diseases. Ann Med. 2005;37(8):546-55.

Quarmby LM, Mahjoub MR.
Caught Nek-ing: cilia and centrioles. J Cell Sci. 2005 Nov 15;118(Pt 22):5161-9.

Davenport JR, Yoder BK.
An incredible decade for the primary cilium: a look at a once-forgotten organelle. Am J Physiol Renal Physiol. 2005 Dec;289(6):F1159-69.

Kohl L, Bastin P.
The flagellum of trypanosomes. Int Rev Cytol. 2005;244:227-85.

Carlen B, Stenram U.
Primary ciliary dyskinesia: a review. Ultrastruct Pathol. 2005 May-Aug;29(3-4):217-20.

Quarmby LM, Parker JD.
Cilia and the cell cycle? J Cell Biol. 2005 Jun 6;169(5):707-10.

Gerdes JM, Katsanis N.
Microtubule transport defects in neurological and ciliary disease. Cell Mol Life Sci. 2005 Jul;62(14):1556-70.

Beales PL.
Lifting the lid on Pandora's box: the Bardet-Biedl syndrome. Curr Opin Genet Dev. 2005 Jun;15(3):315-23.

Eley L, Yates LM, Goodship JA.
Cilia and disease. Curr Opin Genet Dev. 2005 Jun;15(3):308-14.

Badano JL, Teslovich TM, Katsanis N.
The centrosome in human genetic disease. Nat Rev Genet. 2005 Mar;6(3):194-205.

Pan J, Wang Q, Snell WJ.
Cilium-generated signaling and cilia-related disorders. Lab Invest. 2005 Apr;85(4):452-63.

Praetorius HA, Spring KR.
A physiological view of the primary cilium. Annu Rev Physiol. 2005;67:515-29.

Afzelius BA.
Cilia-related diseases. J Pathol. 2004 Nov;204(4):470-7.

Scholey JM, Ou G, Snow J, Gunnarson A.
Intraflagellar transport motors in Caenorhabditis elegans neurons. Biochem Soc Trans. 2004 Nov;32(Pt 5):682-4.

Pazour GJ.
Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J Am Soc Nephrol. 2004 Oct;15(10):2528-36.

Bossinger O, Bachmann A.
Ciliogenesis: polarity proteins on the move. Curr Biol. 2004 Oct 5;14(19):R844-6.

Salisbury JL.
Primary cilia: putting sensors together. Curr Biol. 2004 Sep 21;14(18):R765-7.

Zhang Q, Taulman PD, Yoder BK.
Cystic kidney diseases: all roads lead to the cilium. 2004 Aug;19:225-30.

Pazour GJ.
Comparative genomics: prediction of the ciliary and basal body proteome. Curr Biol. 2004 Jul 27;14(14):R575-7.

Yokoyama T.
Motor or sensor: a new aspect of primary cilia function. Anat Sci Int. 2004 Jun;79(2):47-54.

Wilson PD.
Polycystic kidney disease: new understanding in the pathogenesis. Int J Biochem Cell Biol. 2004 Oct;36(10):1868-73.

Snell WJ, Pan J, Wang Q.
Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders. Cell 2004 Jun 11;117(6):693-7.

Whitfield JF.
The neuronal primary cilium--an extrasynaptic signaling device. Cell Signal. 2004 Jul;16(7):763-7.

Quarmby LM.
Cellular deflagellation. Int Rev Cytol. 2004;233:47-91.

Fuchs JL, Schwark HD.
Neuronal primary cilia: a review. Cell Biol Int. 2004;28(2):111-8.

Scholey JM.
Intraflagellar transport. Annu Rev Cell Dev Biol. 2003;19:423-43.

Dutcher SK.
Elucidation of basal body and centriole functions in Chlamydomonas reinhardtii. Traffic 2003 Jul;4(7):443-51.

Cole DG.
The intraflagellar transport machinery of Chlamydomonas reinhardtii. Traffic 2003 Jul;4(7):435-42.

Ibanez-Tallon I, Heintz N, Omran H.
To beat or not to beat: roles of cilia in development and disease. Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R27-35.

Pazour GJ, Witman GB.
The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol. 2003 Feb;15(1):105-10.

Pazour GJ, Rosenbaum JL.
Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol. 2002 Dec;12(12):551-5.

Woolley D.
The molecular motors of cilia and eukaryotic flagella. Essays Biochem. 2000;35:103-15.

Rosenbaum JL, Witman GB.
Intraflagellar transport. Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25.

Kierszenbaum AL.
Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail. Mol Reprod Dev. 2002 Sep;63(1):1-4.

Sloboda RD.
A healthy understanding of intraflagellar transport. Cell Motil Cytoskeleton. 2002 May;52(1):1-8.

Hagiwara H, Ohwada N, Aoki T, Takata K.
Ciliogenesis and ciliary abnormalities. Med Electron Microsc. 2000;33(3):109-14.

Silflow CD, Lefebvre PA.
Assembly and motility of eukaryotic cilia and flagella. Lessons from Chlamydomonas reinhardtii. Plant Physiol. 2001 Dec;127(4):1500-7.

DiBella LM, King SM.
Dynein motors of the Chlamydomonas flagellum. Int Rev Cytol. 2001;210:227-68.

Bioinformatic, genomic and proteomics studies aimed at defining the ciliome

Mayer U, Ungerer N, Klimmeck D, Warnken U, Schnölzer M, Frings S, Möhrlen F.
Proteomic Analysis of a Membrane Preparation from Rat Olfactory Sensory Cilia. Chem Senses. 2007 Nov 20; [Epub ahead of print].

Laurençon A, Dubruille R, Efimenko E, Grenier G, Bissett R, Cortier E, Rolland V, Swoboda P, Durand B.
Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species. Genome Biol. 2007 Sep 17;8(9):R195.

Liu Q, Tan G, Levenkova N, Li T, Pugh EN Jr, Rux JJ, Speicher DW, Pierce EA.
The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics. 2007 Aug;6(8):1299-317.

Broadhead R, Dawe HR, Farr H, Griffiths S, Hart SR, Portman N, Shaw MK, Ginger ML, Gaskell SJ, McKean PG, Gull K.
Flagellar motility is required for the viability of the bloodstream trypanosome. Nature 2006 Mar 9;440(7081):224-7.

Pazour GJ, Agrin N, Leszyk J, Witman GB.
Proteomic analysis of a eukaryotic cilium. J Cell Biol. 2005 Jul 4;170(1):103-13.

Stolc V, Samanta MP, Tongprasit W, Marshall WF.
Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3703-7.

Smith JC, Northey JG, Garg J, Pearlman RE, Siu KW.
Robust method for proteome analysis by MS/MS using an entire translated genome: demonstration on the ciliome of Tetrahymena thermophila. J Proteome Res. 2005 May-Jun;4(3):909-19.

Blacque OE, Perens EA, Boroevich KA, Inglis PN, Li C, Warner A, Khattra J, Holt RA, Ou G, Mah AK, McKay SJ, Huang P, Swoboda P, Jones SJ, Marra MA, Baillie DL, Moerman DG, Shaham S, Leroux MR.
Functional genomics of the cilium, a sensory organelle. Curr Biol. 2005 May 24;15(10):935-41.

Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P.
Analysis of xbx genes in C. elegans. Development 2005 Apr;132(8):1923-34.

Li JB, Gerdes JM, Haycraft CJ, Fan Y, Teslovich TM, May-Simera H, Li H, Blacque OE, Li L, Leitch CC, Lewis RA, Green JS, Parfrey PS, Leroux MR, Davidson WS, Beales PL, Guay-Woodford LM, Yoder BK, Stormo GD, Katsanis N, Dutcher SK.
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 2004 May 14;117(4):541-52.

Avidor-Reiss T, Maer AM, Koundakjian E, Polyanovsky A, Keil T, Subramaniam S, Zuker CS.
Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 2004 May 14;117(4):527-39.

Ostrowski LE, Blackburn K, Radde KM, Moyer MB, Schlatzer DM, Moseley A, Boucher RC.
A proteomic analysis of human cilia: identification of novel components. Mol Cell Proteomics 2002 Jun;1(6):451-65.

Studies aimed at uncovering the centrosomal/basal body proteome

Kilburn CL, Pearson CG, Romijn EP, Meehl JB, Giddings TH Jr, Culver BP, Yates JR 3rd, Winey M.
New Tetrahymena basal body protein components identify basal body domain structure. J Cell Biol. 2007 Sep 10;178(6):905-12.

Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M.
Proteomic characterization of the human centrosome by protein correlation profiling. Nature 2003 Dec 4;426(6966):570-4.

Keller LC, Romijn EP, Zamora I, Yates JR 3rd, Marshall WF.
Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr Biol. 2005 Jun 21;15(12):1090-8.