The Molecular Cardiac Physiology Group comprises faculty from the Departments of Biomedical Physiology and Kinesiology (Drs. Tom Claydon, Damon Poburko, Peter Ruben, Glen Tibbits) and Molecular Biology and Biochemistry (Drs. Mark Paetzel, Edgar Young).
The group studies the molecular and cellular mechanisms of cardiac excitation and excitation-contraction coupling. The MCPG are housed in a joint lab in the Technology and Science Complex (TASCII) building at the SFU Burnaby campus in Greater Vancouver, British Columbia, Canada.
Our work focuses on congenital heart diseases such as dysfunction of cardiac ion channels(channelopathies) and contractile proteins (cardiomyopathies) both of which can result in arrhythmias and sudden cardiac death.
This strong research focus has close working ties with adult and pediatric cardiologists, as well as with systems level physiology research in areas such as autonomic cardiovascular control, the effects and mechanisms of autonomic dysfunction (e.g. spinal cord injury and chronic exposure to hypoxia), cardiac arrhythmia, and syncope.
We therefore approach cardiovascular function and dysfunction from an integrative perspective encompassing molecular to systems physiology. This provides an integrative “bench-to-bedside” approach to the study of cardiovascular physiology and pathophysiology.