Simon Fraser University
Engaging the World

Course Outlines

Fall 2018 - BPK 412 D100

Molecular Cardiac Physiology (3)

Class Number: 4866

Delivery Method: In Person

Overview

  • Course Times + Location:

    Sep 4 – Dec 3, 2018: Tue, Thu, 9:30–10:20 a.m.
    Burnaby

  • Exam Times + Location:

    Dec 11, 2018
    Tue, 8:30–11:30 a.m.
    Burnaby

  • Prerequisites:

    BPK 305.

Description

CALENDAR DESCRIPTION:

This course entails a detailed analysis of the molecular and cellular basis of cardiac function. The material will be derived from myriad disciplines including: structure (histology and ultrastructure, molecular), biophysics, biomechanics, physiology, electrophysiology, biochemistry and molecular biology. A particular emphasis will be placed on the mechanisms by which inherited arrhythmias and cardiomyopathies manifest as a pathological phenotype.

COURSE DETAILS:

The course presents a detailed analysis of the mechanistic basis of cardiac function. The material will be derived from a variety of disciplines including anatomy (histology and ultrastructure), biomechanics, physiology, electrophysiology, biochemistry and molecular biology. There is an an emphasis on cardiac contractile function, ion channels, channelopathies, cardiac arrhythmias and cardiomyopathies and the use of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) in their diagnosis and treatment. Course structure: two hours of lecture and one hour tutorial per week.

BRIEF COURSE OUTLINE
Cardiac Structure

  • Anatomy, Histology and Ultrastructure
Cardiac Excitation
  • Electrophysiology, Channelopathies, Cardiac arrhythmias and ECG
  • Excitation-contraction coupling
Cardiac Contraction
  • Biomechanics of cardiac contraction; Cardiac contractile proteins
  • Hypertrophic Cardiomyopathies
Cardiac Development

Grading

  • Tutorial Presentation (debate) 20%
  • Paper 20%
  • Midterm 20%
  • Final 40%

NOTES:

TUTORIAL
The tutorial serves several purposes. First, it allows for the communication of new material that is best presented to a smaller audience. Second, questions and problems can be explored in greater detail. Third, this is a forum for formal debates on controversial issues in the field.

Materials

REQUIRED READING:

None

RECOMMENDED READING:

While there is no required text, the following texts will be on reserve in the library:

Excitation-contraction coupling and cardiac contractile force QP 113.2 B47 2001
D.M. Bers, Kluwer Scientific Press (2001) ISBN: 0-7923-7158-5

Ion channels of excitable membranes (3rd Edition) QH 603 I54 H54 2001
Bertil Hille, Sinauer Associates (2001) ISBN: 0-8789-3321-2

Cardiac Electrophysiology: From Cell to Bedside (6th Edition)
D. Zipes and J. Jaliffe, Saunders (2014) ISBN: 978-1-4557-2856-5
This e-book is available at: http://www.sciencedirect.com/science/book/9781455728565

Department Undergraduate Notes:

It is the responsibility of the student to keep their BPK course outlines if they plan on furthering their education.

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS