Fall 2018 - MBB 423 D100
Protein Structure and Function (3)
Class Number: 4725
Delivery Method: In Person
Course Times + Location:
Sep 4 – Dec 3, 2018: Wed, 10:30 a.m.–12:20 p.m.
Sep 4 – Dec 3, 2018: Fri, 10:30 a.m.–12:20 p.m.
1 778 782-4751
Prerequisites:MBB 323 or MBB 324, with a minimum grade of C.
Mechanistic principles for how protein molecules achieve diverse functions such as chemical catalysis and conformational switching. Students will learn to critique hypotheses about structural mechanisms, and to interpret the primary literature reporting on structural evidence from X-ray diffraction and spectroscopy.
In Part 1 of the course (weeks 1-10), students will learn to assess primary literature reports of experimental data on structure and function, and to formulate hypotheses and apply structural reasoning in investigations of molecular mechanism.
In Part 2 of the course (weeks 11-13), students will use skills from Part 1 to give an oral presentation and to write a paper summarizing examples of research literature on a selected protein.
Structural basis of protein function:
- Stability and flexibility
- Enzymatic catalysis
- Integrating multiple functions
- X-ray crystallography
- Electron microscopy
- Spectroscopic techniques
- Part 1 - Short Quizzes/iClicker in class 10%
- Part 1 - Exams (2) in class 50%
- Part 2 - Oral presentation and Written paper 40%
- Grading is subject to change depending on enrolment.
MATERIALS + SUPPLIES:
iClicker transmitter required during lectures (available from SFU Bookstore).
This course is not textbook-based. Course readings and research journal articles will be available in Library Reserves.
Department Undergraduate Notes:
- Students are advised to review the plagiarism tutorial found at
- For help with writing, learning and study strategies please contact the Student Learning Commons at
- Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail: firstname.lastname@example.org)
SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.
Each student is responsible for his or her conduct as it affects the University community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS