Fall 2018 - MBB 440 D100
Selected Topics in Contemporary Molecular Biology (3)
Class Number: 9555
Delivery Method: In Person
Course Times + Location:
Sep 4 – Dec 3, 2018: Tue, 8:30–10:20 a.m.
Sep 4 – Dec 3, 2018: Thu, 8:30–10:20 a.m.
Prerequisites:will depend upon the nature of the topic offered.
The topics in this course will vary from term to term, depending on faculty availability and student interest.
Description:An examination of the genomic changes that accrue during the formation and treatment of human cancer.
The course will examine the role that genetic mutations play in the development of human cancer and tumour formation. We will study the spectrum of different types of genetic alterations that accrue and their distribution across different cancer types. We will study the technologies that allow these changes to be detected and how they are interpreted clinically. The course will explore how different mutations can be correlated with specific therapeutics and how further genetic mutations can lead to treatment resistance.
- Cancer sequencing
- Tumour heterogeneity
- DNA repair
- Hereditary cancer
- Treatment resistance
- Neo-antigens and immunotherapy
- Cancer epigenomics
- Personalized oncogenomics
- Mutational signatures
- Midterm 40%
- Final 60%
Prerequisites:MBB322, MBB331 and MBB342 with a minimum grade of C or permission of the instructor.
The Biology of Cancer, 2nd Ed, Robert A. Weinberg, 2014, Garland Publishing (for background reading).
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