Overview

Description

CALENDAR DESCRIPTION:

An advanced, in-depth treatment of a specialized area of organic chemistry.

COURSE DETAILS:

Advanced Organic Structure Analysis

2 lecture hours/week; 1 tutorial hour/week

This course is designed to provide a complete training in the practical aspects of modern structure determination using the latest NMR and MS methods. It includes both the required level of theory to allow students to make informed decisions about experimental design and execution and a detailed coverage of the practical aspects of structure elucidation. In keeping with the philosophy of practical relevance students will be required to process their own 1D and 2D NMR spectra in the computer lab sessions, and to interpret these data in order to solve complex structural problems.

This course will cover:

• The theory of NMR signal generation
• Understanding the NMR spectrometer
• Basic and advanced one-dimensional NMR experiments (acquisition, processing and interpretation)
• Basic and advanced two-dimensional NMR experiments (acquisition, processing and interpretation)
• NMR experiments with nuclei other than 1H and 13C
• Strategies for complex structure elucidation
• The theory of MS signal generation
• Detailed examination of mass sprectrometer design
• Applications of mass spectrometry in organic synthesis, and strategies for selecting appropriate instruments for a given problem
• Cutting edge mass spectrometry tools including imaging mass spec, DESI, DART, NIMS and molecular networking
• Approaches for integrating NMR and mass spectrometry data into structure elucidation problems

COURSE-LEVEL EDUCATIONAL GOALS:

The central educational objective of this course is to provide students with a clear view of the analytical tools available to help with complex organic chemistry structure elucidation challenges, and to provide students with strategies for selecting the correct analytical approach to solve complex structural problems. To accomplish this, students will be trained in the theory of signal generation, details of hardware design and optimization, in-depth discussion of experimental methods using a variety of hardware configurations, and theoretical and practical exposure to selecting and implementing these analytical tools for structure elucidation. At the end of the course, students should be well versed in all of the modern analytical tools available for organic structure elucidation, and be able to design and execute analytical strategies for complex structure elucidation problems.

Grading

Materials

REQUIRED READING:

RECOMMENDED READING: