Fall 2019 - MBB 461 D100

Comparative Genomics (3)

Class Number: 1980

Delivery Method: In Person


  • Course Times + Location:

    Sep 3 – Dec 2, 2019: Tue, Thu, 2:30–4:20 p.m.

  • Prerequisites:

    MBB 331 and MBB 342, with a minimum grade of C.



Examination of the fundamentals of comparative genomics, identification and activity of functional elements in genomes, inter- and intra-species comparisons, relationship of genomic to phenotypic variation, and personalized genomics are among the topics to be explored. Comparison of genome data has impacts on medicine and many other fields of the life sciences. Students who have completed MBB 440 Comparative Genomics may not complete this course for further credit.


Module 1: Fundamentals
Lecture 1: Comparative genomics: an emerging field
Lecture 2: DNA sequencing technologies: the driving force
Lecture 3: Bioinformatics: the enabling force
Lecture 4: Resources for comparative genomics
Lecture 5: The Human Genome Project
Module 2: Functional elements: identification and function
Lecture 6: Gene
Lecture 7: Ultraconserved elements
Lecture 8: Functional elements: cis-regulatory elements
Lecture 9: ENCODE & MOD-ENCODE projects
Lecture 10: Synteny blocks
Lecture 11: Genome rearrangement events and genome evolution
Module 3: Intra-species comparison
Lecture 12: Genomic variations
Lecture 13: From SNP to HapMap
Lecture 14: Structural variations
Lecture 15: Loss-of-function variations
Lecture 16: Exome sequencing
Lecture 17: Personalized genomes and The 1000 Genome Project
Module 4: Inter-species comparison
Lecture 18: Genome family expansion and contraction
Lecture 19: Transcription factor and gene battery
Lecture 20: Horizontal gene transfer
Lecture 21: Virulence factors and drug targets
Lecture 22: Metagenomics
Lecture 23: What makes us human?
Lecture 24: The Genome 10K Project


  • Quizzes 25%
  • Presentation 25%
  • Participation 10%
  • Report 40%

Department Undergraduate Notes:

  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html