Spring 2020 - MBB 427 D100
Immune Responses in Health and Disease (3)
Class Number: 2785
Delivery Method: In Person
Course Times + Location:
We, Fr 2:30 PM – 4:20 PM
AQ 3153, Burnaby
Prerequisites:One of MBB 326, HSCI 326, MBB 426 or HSCI 426, with a minimum grade of C, or permission of the instructor.
Defects in the immunologic response to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for HSCI 427 cannot take MBB 427 for credit.
Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunopathologies with emphasis on diagnostics and therapies, especially emerging immunotherapies (therapeutic antibodies, CAR-T cells, cellular engineering), as well as vaccination.
- Review of innate and adaptive immunity
- Immunity to microbes
- Vaccines and their mechanisms of action
- Transplantation immunology
- Immunity to tumors
- Hypersensitivity disorders
- Congenital immunodeficiencies
COURSE-LEVEL EDUCATIONAL GOALS:
Understand the physiological, cellular, molecular and genetic bases of a range of immunopathologies. Develop insights into immunosurveillance and how cancer and organ transplantation overcome immune responses. Gain depth in the use of current technologies, including immunotherapies. Improve skills developed in MBB/HSCI 426/726 to review and critique papers in the primary literature, in both oral and written formats.
- 3 non-cumulative exams (20% each) 60%
- Class participation 10%
- 1 in-class presentation with written summary and critique. 30%
Original research articles and review articles
The Immune System, 4th Ed., Peter Parham, 2015. Garland Science.
Department Undergraduate Notes:
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- Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail: firstname.lastname@example.org)
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