Spring 2023 - MBB 465 D100
Cancer Genomics (3)
Class Number: 5962
Delivery Method: In Person
Course Times + Location:
We, Fr 10:30 AM – 12:20 PM
RCB 8100, Burnaby
1 778 782-9581
Prerequisites:MBB 331 and MBB 342 with a minimum grade of C or permission of the instructor.
Our understanding of the role of genetic and epigenetic changes in the formation of human cancers continues to be advanced by genomic technologies. Current techniques for studying cancer genomes and how heritable changes can lead to treatment resistance will be discussed. Students with credit for MBB 460 under the title "Cancer Genomics" may not take this course for further credit.
An examination of the genomic changes that accrue during the formation and treatment of human cancer.
The course will examine the role that genetic mutations play in the development of human cancer and tumour formation. We will study the spectrum of different types of genetic alterations that accrue and their distribution across different cancer types. We will study the technologies that allow these changes to be detected and how they are interpreted clinically. Students with credit for MBB 460 under the title "Cancer Genomics" may not take this course for further credit.
- Cancer sequencing
- Tumour heterogeneity
- DNA repair
- Hereditary cancer
- Treatment resistance
- Neo-antigens and immunotherapy
- Cancer epigenomics
- Gene expression and alternative splicing in cancer
- Personalized oncogenomics
- Mutational signatures
- Quizzes 40%
- In-class presentation 20%
- Written assignment 30%
- Class participation 10%
REQUIRED READING NOTES:
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Department Undergraduate Notes:
- For help with writing, learning and study strategies please contact the Student Learning Commons at
- Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail: email@example.com)
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