Simon Fraser University
Engaging the World

Course Outlines

Spring 2024 - HSCI 440 D100

Cell Pathophysiology Laboratory (4)

Class Number: 4434

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 8 – Apr 12, 2024: Thu, 1:30–5:20 p.m.
    Burnaby

  • Prerequisites:

    HSCI 321, HSCI 323, and one of BISC 357, MBB 308, or MBB 309W, all with a minimum grade of C-.

Description

CALENDAR DESCRIPTION:

A review of pathophysiological mechanisms of disease with an emphasis on the molecular, cellular and genetic bases of pathology. Laboratory includes cell-biology experiments, histological preparations, and microscopic examination of normal and diseased tissues.

COURSE DETAILS:

This course will provide students with hands-on experience in techniques in molecular biology, biochemistry and cell biology to investigate mechanisms involved in cellular pathophysiology. Topics will include cell growth, apoptosis, cell differentiation and cell migration.

The objectives of this course are to provide students with knowledge in research techniques that can be used to investigate topics in cell biology as it relates to biological mechanisms governing disease pathogenesis in humans. At the end of this course students are expected to be able to discuss the basis for normal and pathological states at the molecular, cellular and tissue level. In addition, students are expected to demonstrate understanding of techniques used to interpret the experimental results and relate that to data from other scientific journals.

COURSE-LEVEL EDUCATIONAL GOALS:

  • Explain how laboratory research techniques and experimental methodology can be used to investigate cell biology as it relates to mechanisms governing disease pathogenesis in humans.
  • Conduct mammalian cell culture-based experiments that are used to investigate mechanisms involved in cellular pathophysiology.
  • Interpret and critique the experimental observations, results, and data and relate these to current models and mechanisms of human pathophysiology.

Grading

  • Laboratory reports (2x30%) 60%
  • Online assignments (6x5%) 30%
  • Pre-lab assignments/quizzes (5x2%) 10%

Materials

MATERIALS + SUPPLIES:

Students will be required to wear personal protective equipment (PPE) in the laboratory. This includes a lab coat, disposable gloves, and safety glasses. Face masks are optional.  PPE will be available in the laboratory for students, but students may bring and use their own if they choose.  The use of a laboratory notebook required.

REQUIRED READING NOTES:

Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity website http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the university community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the university. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the university. http://www.sfu.ca/policies/gazette/student/s10-01.html