Whole Brain Registration
OverviewInter-subject registration of whole brain magnetic resonance images is a challenging problem because of the high anatomical variability and the convoluted folding of the cortex. Applications of non-rigid registration are vast and include morphometry, functional localization, and atlas creation.
Our approach is to use automated Freesurfer segmentations of multiple brain structures as simultaneous anatomic constraints (multi-structure registration).
- Freesurfer subcortical and cortical segmentation
- Perform multi-structure confidence-weighted LDDMM registration
- 16 subcortical and 35 cortical structures used in multi-structure registration
- Provides anatomical constraints to help guide the high-dimensional registration
- Multi-structure LDDMM registration compared against:
- Free-form deformation B-splines (IRTK, Rueckert et al.)
- Single channel LDDMM
- 1.5T brain MR scans from the Internet Brain Segmentation Repository (IBSR)
- Cortical surface distances:
- Propagated cortical surfaces:
- Subcortical overlap:
Relevant publicationsKhan, A., Beg, M. F. 2009
Multi-structure whole brain registration and population average
IEEE Engineering in Medicine and Biology Conference (EMBC 2009). Poster (PDF).
Khan, A., Beg, M. F. 2009
Whole brain image registration using multi-channel confidence-weighted anatomic constraints
Organization for Human Brain Mapping Meeting (HBM 2009). Poster (PDF)