Automated Brain Mapping

Whole Brain Registration

Overview

Inter-subject registration of whole brain magnetic resonance images is a challenging problem because of the high anatomical variability and the convoluted folding of the cortex. Applications of non-rigid registration are vast and include morphometry, functional localization, and atlas creation.

Our approach is to use automated Freesurfer segmentations of multiple brain structures as simultaneous anatomic constraints (multi-structure registration).

Methods

• Freesurfer subcortical and cortical segmentation

• Perform multi-structure confidence-weighted LDDMM registration
• 16 subcortical and 35 cortical structures used in multi-structure registration
• Provides anatomical constraints to help guide the high-dimensional registration

Results

• Multi-structure LDDMM registration compared against:
• Free-form deformation B-splines (IRTK, Rueckert et al.)
• Single channel LDDMM
• 1.5T brain MR scans from the Internet Brain Segmentation Repository (IBSR)

• Cortical surface distances:

• Propagated cortical surfaces:

• Subcortical overlap:

Relevant publications

Khan, A., Beg, M. F. 2009
Multi-structure whole brain registration and population average
IEEE Engineering in Medicine and Biology Conference (EMBC 2009). Poster (PDF).

Khan, A., Beg, M. F. 2009
Whole brain image registration using multi-channel confidence-weighted anatomic constraints
Organization for Human Brain Mapping Meeting (HBM 2009). Poster (PDF)