OverviewConstructing a one to one correspondence between whole brain MR image scans is a problem of critical importance in neuroimaging analyses. We have developed a framework to combine the strength of both surface-based and volumetric-based analyses for consistent, bijective data transfer between brain coordinate systems.
MethodsThe figure below outlines the steps in the SAVOR pipeline:
- Two pial surfaces
- Upper surface registered to lower surface via image registration, with identity coordinate functions overlaid.
- Surfaces mapped to the spherical domain via FreeSurfer mapping with coordinate functions overlaid.
- Surfaces on spherical domain with function on lower surface mapped to that on upper surface, via Spherical Demons.
- Cortical thickness values for upper and lower brains displayed on the domain of the lower brain.
- Average surface-registration error map, quantifying the variability in label overlaps after registration:
- Mean longitudinal change in cortical thickness for an 8 subject cohort, mapped on to a common template:
Relevant publicationsGibson, A., Khan, A., Beg, M. F. 2009
A combined Surface And VOlumetric Registration (SAVOR) framework to study cortical biomarkers and volumetric imaging data
MICCAI 2009. LNCS 5761: 713-724. Poster (PDF)