Fall 2016 - MBB 422 D100
Class Number: 1426
Delivery Method: In Person
Course Times + Location:
We, Fr 8:30 AM – 10:20 AM
SECB 1014, Burnaby
Exam Times + Location:
Dec 17, 2016
12:00 PM – 3:00 PM
AQ 5016, Burnaby
1 778 782-3709
Prerequisites:MBB 322 and MBB 309W with a minimum grade of C, MBB 324 as a pre or co-requisite.
A review of recent research on the structure, dynamics, function and biosynthesis of membranes, membrane lipids and proteins.
- Paradigms of membrane organization and physical properties, chemical structures of lipids; hydrophobic effect, model membranes
- Membrane Lipid dynamics and phase properties, effects of cholesterol
- Characterization of membranes using physical techniques: diffraction, magnetic resonance (NMR/ESR)
- Lipid Polymorphism, shape theory;
- Protein rotational and translational dynamics
- Membrane surface potential
- Membrane asymmetry and lipid microdomains (RAFTS) - methods, characterization and function(s).
- Topography analysis of integral membrane proteins
- hydropathy analysis
- helix-helix interactions
- folding and insertion pathways for helix bundles and beta barrels
- Integral membrane protein – lipid interactions: principles
- Modulation of integral membrane protein conformation by specific lipid or ligand interactions.
- mechanosensitive ion channels
- voltage-gated ion channels
- Peripheral membrane proteins, structure and lipid interactions
- Lipid covalent anchors
- Lipid binding modules: amphipathic helix anchors
- Peripheral proteins perturb lipid bilayers - curvature induction; fusion
- Assignments 45%
- Class Presentation 20%
- Attendance/Participation 10%
- Final Exam (open book) 25%
Luckey, Mary, Membrane Structural Biology with Biochemical and Biophysical Foundations,2nd Ed., 2014. Cambridge University Press.
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- Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail: firstname.lastname@example.org)
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ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS