Fall 2016 - MBB 422 D100

Biomembranes (3)

Class Number: 1426

Delivery Method: In Person


  • Course Times + Location:

    We, Fr 8:30 AM – 10:20 AM
    SECB 1014, Burnaby

  • Exam Times + Location:

    Dec 17, 2016
    12:00 PM – 3:00 PM
    AQ 5016, Burnaby

  • Prerequisites:

    MBB 322 and MBB 309W with a minimum grade of C, MBB 324 as a pre or co-requisite.



A review of recent research on the structure, dynamics, function and biosynthesis of membranes, membrane lipids and proteins.



  1. Paradigms of membrane organization and physical properties, chemical structures of lipids; hydrophobic effect, model membranes
  2. Membrane Lipid dynamics and phase properties, effects of cholesterol
  3. Characterization of membranes using physical techniques: diffraction, magnetic resonance (NMR/ESR)
  4. Lipid Polymorphism, shape theory;
  5. Protein rotational and translational dynamics
  6. Membrane surface potential
  7. Membrane asymmetry and lipid microdomains (RAFTS) - methods, characterization and function(s).
  8. Topography analysis of integral membrane proteins
    • hydropathy analysis
    • helix-helix interactions
    • folding and insertion pathways for helix bundles and beta barrels
  9. Integral membrane protein – lipid interactions: principles
  10. Modulation of integral membrane protein conformation by specific lipid or ligand interactions.
    • mechanosensitive ion channels
    • rhodopsin
    • voltage-gated ion channels
  11. Peripheral membrane proteins, structure and lipid interactions
    • Lipid covalent anchors
    • Lipid binding modules: amphipathic helix anchors
  12. Peripheral proteins perturb lipid  bilayers - curvature induction; fusion


  • Assignments 45%
  • Class Presentation 20%
  • Attendance/Participation 10%
  • Final Exam (open book) 25%



Luckey, Mary, Membrane Structural Biology with Biochemical and Biophysical Foundations,2nd Ed., 2014. Cambridge University Press.
ISBN: 978-1-107-03063-3

Department Undergraduate Notes:

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Registrar Notes:

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