Fall 2016 - MBB 426 D100

Immune System I: Basis of Innate and Adaptive Immunity (4)

Class Number: 1427

Delivery Method: In Person


  • Course Times + Location:

    Sep 6 – Dec 5, 2016: Mon, Fri, 2:30–3:20 p.m.

    Sep 6 – Dec 5, 2016: Wed, 2:30–4:20 p.m.

  • Instructor:

    Jamie Scott
    1 778 782-5658
    Office: South Science Bldg (SSB) 7144
    Office Hours: Wed. 4:30-5:20 PM Meet in classroom BLU 9011
  • Prerequisites:

    MBB 331 with a minimum grade of C.



The basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system. Innate, antibody and cellular immune responses and their control, and development of the cells involved in these responses. Students who have taken HSCI 325 or HSCI 425 cannot take MBB 426 for further credit.


4 lecture hours/week; 1 tutorial hour/week; 0 lab hours

The course will consist of lectures, based almost entirely on the readings in the required textbook, weekly iClicker tests, weekly in-class activities, an 11-min presentation of a paper from the primary immunology literature in tutorial, and accompanying 2-page summary of it, as well as attendence and participation in tutorials. Much of the tutorial time will be spent in developing the student presentations. Groups of 3-4 students will be responsible for developing a presentation and summary for an assigned paper.

Should the class decide, there will be 4 in-class, non-comprehensive quizzes, and no final examination (otherwise the last quiz will be taken during exam week).  

Further details and a schedule of lectures, readings, presentations and in-class activities will be provided in a syllabus that will be uploaded to the course website.

   Week     Chapter/Lecture Topic

  1. Basic Concepts in Immunology
  2. Innate Immunity: The First Lines of Defense
  3. The Induced Responses of Innate Immunity
  4. Antigen Recognition by B-cell and T-cell Receptors
  5. The Generation of LymphocyteAntigen Receptors Antigen
  6. Presentation to T Lymphocytes
  7. Signaling through Immune System Receptors
  8. The Development and Survival of Lymphocytes I
  9. The Development and Survival of Lymphocytes II
  10. T-cell Mediated Immunity
  11. The Humoral Immune Response
  12. Dynamics of Adaptive Immunity
  13. The Mucosal Immune System


This 4-credit course will be a lot of work, but you will learn a lot of very cool immunology. My intention is for students to develop a firm foundation in the basics of the immune system and how it functions, which will prepare you for advanced immunology courses (e.g., Immune System II (MBB/HSCI 427/727) and Vaccine Immunology (HSCI 477/727)). My goal is for you to become a more independent learner, to become fluent in concepts in the current immunology literature, and to learn to effectively research topics in immunology and communicate the results of that research. In short, I hope to provide you with the basic knowledge and skills to think critically in immunology, and to function successfully in a graduate immunology program (or, really, in any graduate program in cell/molecular biology).


  • Weekly iClicker tests (15 pts) 5%
  • Weekly in-class activities (15 pts) 5%
  • Tutorial participation (10 pts) 3.3%
  • Presentation & summary (50 pts) 16.7%
  • Four 40-min quizzes (210 pts) 70%


The textbook is required for this course, as are attendance and participation in the in-class activities and tutorials.



Please bring your iClicker to your first tutorial so that it can be registered.
Dates of iClicker tests for each chapter will be provided in the full syllabus.


K. Murphy & C. Weaver. Janeway's Immunobiology, 9th Edition. 2016. Garland Publishing.
ISBN: 9780815345053


Those interested in medicine & clinical sciences might like the companion text: R. Geha & L. Notarangelo. Case Studies in Immunology. 7th Ed. 2016. Garland Publishing.
ISBN: 9780815345121

A good reference is Alberts et al., Molecular Biology of the Cell (5th or 6th Ed), 2014 or 2007, respectively, Garland Science, New York.

Department Undergraduate Notes:

  • Students are advised to review the plagiarism tutorial found at
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html