Simon Fraser University
Engaging the World

Course Outlines

Spring 2017 - CHEM 419 D100

Special Topics in Analytical Chemistry (3)

High Throughput Analysis

Class Number: 3272

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 4 – Apr 7, 2017: Tue, Thu, 2:30–4:20 p.m.
    Burnaby

  • Exam Times + Location:

    Apr 19, 2017
    Wed, 3:30–6:30 p.m.
    Burnaby

  • Prerequisites:

    CHEM 316.

Description

CALENDAR DESCRIPTION:

Principles and applications of emerging techniques in analytical chemistry.

COURSE DETAILS:

This course offers an introductory (Undergraduate level) or in-depth (Graduate level) understanding of high-throughput instrumental analysis techniques (proteomics, genomics, metabolomics, imaging) and their applications in diverse disciplines from chemistry, biology, medicine, environmental science, and beyond. The knowledge will be acquired through both in class lecture, lab demonstration, and team project.

Main topics:
1. Tandem Mass Spectrometry (biomolecule structure analysis, proteomics)

  • Instrumentation, methodology design, recent advances, future direction.
2. Nanoflow UHPLC (ultraseparation for complex biosamples, metabolomics)
  • Fundamentals of separation, history of nanoflow separation, suitability to biomolecules, strategies of methodology design
3. Modern sensitive analysis for trace samples (such as single-cell analysis including single-cell DNA, RNA, protein, and imaging analysis)
  • The trend of trace analysis, the uniqueness of sensitive analysis, the boiling pot of future novel bioanalytical techniques
4. Systems Biology (integration of DNA, RNA, protein, small molecules of biological entities)
  • Introduction of the history, characteristics of systems biology; the nature of big data analysis including statistics, simulation, modeling
  • Introduction of the relationship between systems biology and instrumental high-throughput bio-analysis
  • Integration of systems biology to current biological research and biomedical application
  • The future direction and its impact to our daily life

Grading

  • Exam (Comprehensive) 40%
  • Report (Subject Specific) 30%
  • Presentation (Subject Specific) 30%

NOTES:

Graduate students enrolled in this course will be conducting similar presentations, reports, and examinations as undergraduate students, but evaluated with higher standard. In addition, the graduate students may expect several additional assignments, and questions on the examinations.

REQUIREMENTS:

CHEM 316 or permission of the instructor.

Materials

MATERIALS + SUPPLIES:

Course reading materials will be provided throughout the lecture (no labs).

Department Undergraduate Notes:

A grade of C- or better is required for all prerequisite courses.

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS