Fall 2018 - CHEM 180 D100
The Chemistry of Life (3)
Class Number: 5284
Delivery Method: In Person
Overview
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Course Times + Location:
Sep 4 – Dec 3, 2018: Mon, Wed, Fri, 9:30–10:20 a.m.
Burnaby -
Exam Times + Location:
Dec 12, 2018
Wed, 12:00–3:00 p.m.
Burnaby
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Instructor:
John Canal
jcanal@sfu.ca
1 778 782-7661
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Prerequisites:
CHEM 121.
Description
CALENDAR DESCRIPTION:
A basic introduction to chemical kinetics, thermodynamics, electrochemistry, and equilibria as they apply to the structure and function of biomolecules. Concepts will be illustrated using modern examples of biological systems. Students will be introduced to central ideas and selected molecular engineering methods in biochemistry and molecular biology.
COURSE DETAILS:
3 lecture hours/week; 1 tutorial hour/week
Topics
1. Organic Molecules (≈ 3 Lectures)
Drawing organic molecules
Geometry of bonds and bond lengths
Hydrogen Bonds
Electrostatic interactions
Hydrophobic interactions
2. Thermodynamics (≈ 4 Lectures)
Three laws, definitions
Entropy
Enthalpy
Gibbs free energy, spontaneity
3. Chemical Equilibria and Acids/Bases (≈ 5 Lectures)
Le Chatelier's principle
Kw, Keq, pH, pKa
Henderson-Hasselbach Equation
Titration curves
Ionization of amino acid residues
4. Chemical Kinetics (≈ 5 Lectures)
Reaction coordinate diagrams
Basic rate equations
Reaction order
Catalysts (enzymes)
5. Intoduction to Biomolecules (≈ 5 Lectures)
Compartmentalization
Functional localization of Biomolecules
6. Central Dogma of Molecular Biology (≈ 4 Lectures)
Structure of cells
Flow of information in central dogma
Location and significance of molecules
Enzymes involved
7. Nervous System (≈ 9 Lectures) (Integrated Topics)
Electrochemistry overview
Oxidation and reduction
Potential difference / membrane potential
Nernst equation
Neuron cell structure
Synaptic structure
Saltatory transmission
Action potentials
Ion channels
Chemical Neurotransmitters (Acetylcholine)
Acetylcholinesterase
Localization
Enzyme mechanism
Enzyme kinetics
Diffusion limit
Enzyme inhibition
Kinesin
Microtubules
Conformational changes
Proteins as machines that perform work
COURSE-LEVEL EDUCATIONAL GOALS:
- To give engineering students who have taken CHEM 121-4 General Chemistry and Laboratory I sufficient background to enter KIN 208-3 Introduction to Physiological Systems.
- To give science or engineering students who have CHEM 121, but no background in biology, a basic understanding of central concepts of bioorganic chemistry and biochemistry.
Grading
- Assignments 8%
- Quizzes 12%
- Midterm Exam 30%
- Final Exam 50%
NOTES:
Notes are provided in class.
Lectures allocated to each topic are an estimate and may vary slightly.
Materials
MATERIALS + SUPPLIES:
Calculator
Department Undergraduate Notes:
A grade of C- or better is required for all prerequisite courses.
Registrar Notes:
SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.
Each student is responsible for his or her conduct as it affects the University community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS