Spring 2018 - MBB 427 D100

Immune System II: Immune Responses in Health and Disease (3)

Class Number: 3752

Delivery Method: In Person


  • Course Times + Location:

    Jan 3 – Apr 10, 2018: Wed, Fri, 2:30–4:20 p.m.

  • Prerequisites:

    MBB 426 or HSCI 426, with a minimum grade of C, or permission of the instructor.



Defects in the immunologic response to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for HSCI 427 cannot take MBB 427 for credit.


Course Description

Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunodeficiencies, HIV infection, asthma and allergy, autoimmunity, and organ transplantation. Immune responses to cancer and cancer immunotherapy will also be discussed.

Lecture Topics

  1. Evasion and subversion of host defenses by pathogens
  2. Mechanism of action of vaccines
  3. Primary immunodeficiencies
  4. Acquired immunodeficiency
  5. Allergy and hypersensitivity
  6. Physiological induction and maintenance of tolerance
  7. Autoimmunity
  8. Transplantation
  9. Tumor immunology and immunotherapy


  • 2 non-cumulative exams (30% each) 60%
  • 1 in-class presentation with written summary 30%
  • Class participation 10%



Original research articles and review articles

A. K. Abbas et al., Cellular and Molecular Immunology, 9th Ed., Elsevier Inc. 2017. https://www.elsevier.com/books/cellular-and-molecular-immunology/abbas/978-0-323-47978-3

ISBN: 978-0323479783

Department Undergraduate Notes:

  • Students are advised to review the plagiarism tutorial found at
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html