Fall 2019 - MBB 423 D100

Protein Structure and Function (3)

Class Number: 1998

Delivery Method: In Person

Overview

  • Course Times + Location:

    Tu, Th 8:30 AM – 10:20 AM
    AQ 5016, Burnaby

  • Prerequisites:

    MBB 323 or MBB 324, with a minimum grade of C.

Description

CALENDAR DESCRIPTION:

Mechanistic principles for how protein molecules achieve diverse functions such as chemical catalysis and conformational switching. Students will learn to critique hypotheses about structural mechanisms, and to interpret the primary literature reporting on structural evidence from X-ray diffraction and spectroscopy.

COURSE DETAILS:

In Part 1 of the course (weeks 1-10), students will learn to assess primary literature reports of experimental data on structure and function, and to formulate hypotheses and apply structural reasoning in investigations of molecular mechanism.
In Part 2 of the course (weeks 11-13), students will use skills from Part 1 to give an oral presentation and to write a paper summarizing examples of research literature on a selected protein.

Topics
 
Structural basis of protein function: 

  • Stability and flexibility     
  • Enzymatic catalysis    
  • Integrating multiple functions
Obtaining and assessing structural data:
  • X-ray crystallography     
  • Electron microscopy     
  • Spectroscopic techniques

Grading

  • Part 1 - Short Quizzes/iClicker in class 10%
  • Part 1 - Exams (2) in class 50%
  • Part 2 - Oral presentation and Written paper 40%
  • Grading is subject to change depending on enrolment.

Materials

MATERIALS + SUPPLIES:

iClicker transmitter required during lectures (available from SFU Bookstore).

REQUIRED READING:

This course is not textbook-based. Course readings and research journal articles will be available in Library Reserves.

Department Undergraduate Notes:


  • For help with writing, learning and study strategies please contact the Student Learning Commons at
    http://learningcommons.sfu.ca/
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS