Spring 2020 - MBB 427 D100

Immune Responses in Health and Disease (3)

Class Number: 2785

Delivery Method: In Person


  • Course Times + Location:

    Jan 6 – Apr 9, 2020: Wed, Fri, 2:30–4:20 p.m.

  • Prerequisites:

    One of MBB 326, HSCI 326, MBB 426 or HSCI 426, with a minimum grade of C, or permission of the instructor.



Defects in the immunologic response to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for HSCI 427 cannot take MBB 427 for credit.


Course Description

Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunopathologies with emphasis on diagnostics and therapies, especially emerging immunotherapies (therapeutic antibodies, CAR-T cells, cellular engineering), as well as vaccination.

Lecture Topics

  1. Review of innate and adaptive immunity
  2. Autoimmunity
  3. Immunity to microbes
  4. HIV
  5. Vaccines and their mechanisms of action
  6. Transplantation immunology
  7. Immunity to tumors
  8. Hypersensitivity disorders
  9. Allergy
  10. Congenital immunodeficiencies


Understand the physiological, cellular, molecular and genetic bases of a range of immunopathologies. Develop insights into immunosurveillance and how cancer and organ transplantation overcome immune responses. Gain depth in the use of current technologies, including immunotherapies. Improve skills developed in MBB/HSCI 426/726 to review and critique papers in the primary literature, in both oral and written formats.


  • 3 non-cumulative exams (20% each) 60%
  • Class participation 10%
  • 1 in-class presentation with written summary and critique. 30%



Original research articles and review articles

The Immune System, 4th Ed., Peter Parham, 2015.  Garland Science.
ISBN: 978-0-8153-4466-7

Department Undergraduate Notes:

  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html