Fall 2022 - BISC 472 D100
Special Topics in Cells, Molecules and Physiology (3)
Class Number: 1752
Delivery Method: In Person
Selected topics in areas not currently offered within the undergraduate course offerings in the Department of Biological Sciences.
Topic: Stem Cell Biology & Applications
Description: This course will begin with a historical review of key discoveries in stem cell biology and is structured into three modules. In module 1, we will explore the foundational biology of stem cell populations: the defining characteristics and physiological relevance of natural and reprogrammed stem cell types including embryonic, neonatal, adult and induced pluripotent stem cells. In module 2, cutting-edge technological advances involving these various stem cell populations will be explored, including current state-of-the-art approaches in modeling tissue development and genetic diseases. Module 3 will focus on current and impending therapeutic applications of stem cells: implications toward human health, barriers to regulatory approval or commercialization, and ethical considerations in stem cell research and therapies.
- What defines a “stem cell”
- The breadth of embryonic and adult stem cell types
- Stem cells as founders of tissue development, maintenance, and regeneration
- Strategies to obtain pluripotent and somatic stem cells in vitro
- Experimental approaches to examine cell fate decisions
- How to manipulate stem cells to promote tissue development and regeneration
- Modeling genetic diseases in a dish
- The potential of human stem cell therapies
- Ethical considerations in stem cell research and therapies
- Examining fact from fiction in stem cell-based literature and popular press
- Test #1 20%
- Test #2 20%
- Test #3 20%
- Writing project 25%
- Weekly quizzes and participation 15%
This course is based on the primary literature (journal articles), which will be provided as supplementary material. There is no required text book.
Prerequisites:MBB322 or BISC333 with a minimum grade of C or permission of the instructor.
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