Fall 2022 - CHEM 455 D100

Synthetic Organic Chemistry (3)

Class Number: 2840

Delivery Method: In Person

Overview

  • Course Times + Location:

    Tu, Th 8:30 AM – 10:20 AM
    AQ 5047, Burnaby

  • Exam Times + Location:

    Dec 12, 2022
    7:00 PM – 10:00 PM
    WMC 3511, Burnaby

  • Prerequisites:

    CHEM 381 with a minimum grade of C-, or permission of the instructor.

Description

CALENDAR DESCRIPTION:

This course teaches the principles involved in the planning and execution of the synthesis of organic molecules. Emphasis is on synthesis of naturally occurring compounds of biological importance. Quantitative.

COURSE DETAILS:

Please note, this course outline was accurate at the time of publication but is subject to change.

Mode of Instruction:

3 lecture hours/week; 1 tutorial hour/week
Lecture: In-Person, Burnaby Campus
Tutorial: In-Person, Burnaby Campus

Topics:

An advanced treatment of the strategies and tactics that are used in multi-step organic synthesis will be provided (retrosynthetic analysis, protecting groups, linear and convergent synthesis). The principles and uses of modern synthetic methods will be introduced. The approach employed in this course will be to examine the syntheses of biologically active natural products (steroids, terpenes, alkaloids, and polyethers). This will provide a historical perspective of the development of the art and science of total synthesis over the course of the past century. This approach will also illustrate the use of functional group interconversions, carbon-carbon bond formation reactions, organometallic chemistry, asymmetric synthesis, pericyclic reactions and enzymes in total synthesis.

Combined graduate course: CHEM 755 - Synthetic Organic Chemistry (3)

Grading

  • Oral Presentation 20%
  • Midterm Exam 20%
  • Final Exam 60%

Materials

RECOMMENDED READING:

Laszlo Kurti & Barbara Czako. "Strategic Applications of Named Reactions in Organic Synthesis". 1st Edition, 2005. Publisher: Academic Press.
ISBN: 9780123694836

"Advanced Organic Chemistry: Part A. Structure and Mechanisms. Part B. Reaction and Synthesis", Carey and Sundberg, Plenum Press, 1990.
"Advanced Organic Chemistry: Reactions, Mechanisms, and Stucture", March, Wiley, 1985.
"The Logic of Chemical Synthesis", Corey and Chang, Wiley, 1989.
"Designing Organic Syntheses: A Programmed Introduction to the Synthon Approach", Warren, Wiley, 1980.
"Organics Synthesis, the Disconnection Approach", Warren, Wiley, 1982.
"Organics Synthesis: Concepts, Methods, Starting Materials", Fuhrhop and Penzlin, VCH, 1994.
"Classics in Total Synthesis I", Nicolaou and Sorensen, VCH, 1996. (and II, III).
"Classics in Hydrocarbon Chemistry", Hopf, VCH, 2000.

REQUIRED READING NOTES:

Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Department Undergraduate Notes:

A grade of C- or better is required for all prerequisite courses.

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

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Each student is responsible for his or her conduct as it affects the university community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the university. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the university. http://www.sfu.ca/policies/gazette/student/s10-01.html