Simon Fraser University
Engaging the World

Course Outlines

Spring 2023 - MBB 465 D100

Cancer Genomics (3)

Class Number: 5962

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 4 – Apr 11, 2023: Wed, Fri, 10:30 a.m.–12:20 p.m.
    Burnaby

  • Prerequisites:

    MBB 331 and MBB 342 with a minimum grade of C or permission of the instructor.

Description

CALENDAR DESCRIPTION:

Our understanding of the role of genetic and epigenetic changes in the formation of human cancers continues to be advanced by genomic technologies. Current techniques for studying cancer genomes and how heritable changes can lead to treatment resistance will be discussed. Students with credit for MBB 460 under the title "Cancer Genomics" may not take this course for further credit.

COURSE DETAILS:

An examination of the genomic changes that accrue during the formation and treatment of human cancer.

The course will examine the role that genetic mutations play in the development of human cancer and tumour formation. We will study the spectrum of different types of genetic alterations that accrue and their distribution across different cancer types.   We will study the technologies that allow these changes to be detected and how they are interpreted clinically. Students with credit for MBB 460 under the title "Cancer Genomics" may not take this course for further credit.

Topics include:

  • Cancer sequencing
  • Tumour heterogeneity
  • DNA repair
  • Hereditary cancer
  • Treatment resistance
  • Neo-antigens and immunotherapy  
  • CART-therapies
  • Cancer epigenomics
  • Gene expression and alternative splicing in cancer
  • Personalized oncogenomics
  • Mutational signatures

Grading

  • Quizzes 40%
  • In-class presentation 20%
  • Written assignment 30%
  • Class participation 10%

Materials

REQUIRED READING NOTES:

Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Department Undergraduate Notes:


  • For help with writing, learning and study strategies please contact the Student Learning Commons at
    http://learningcommons.sfu.ca/
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity website http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the university community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the university. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the university. http://www.sfu.ca/policies/gazette/student/s10-01.html