Spring 2015 - MBB 727 G100

Immune System II: Immune Responses in Health and Disease (3)

Class Number: 4007

Delivery Method: In Person


  • Course Times + Location:

    Jan 6 – Apr 13, 2015: Wed, Fri, 2:30–4:20 p.m.

  • Prerequisites:

    MBB 426 or HSCI 426 or permission of the instructor.



The immunologic response to bacterial, viral and parasitic infections, immunological diseases, such as autoimmune diseases, immunodeficiency, hypersensitivity reactions (including asthma and allergy and transplantation-rejection reactions. Immunotherapeutics and vaccine development. Students with credit for MBB 427, HSCI 427, or HSCI 727 may not complete MBB 727 for credit


Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunodeficiencies, HIV infection, asthma and allergy, autoimmunity, and organ transplantation. Immune responses to cancer and cancer immunotherapy will also be discussed.

Lecture Topics
1.      Evasion and subversion of host defenses by pathogens
2.      Human immunodeficiencies
3.      Acquired immunodeficiency
4.      Allergy and hypersensitivity
5.      Physiological induction and maintenance of tolerance
6.      Autoimmunity
7.      Transplantation
8.      Tumor immunology and immunotherapy


  • Non-cumulative exams (2 x 30%) 60%
  • One individual in-class presentation with written summary 30%
  • Class participation 10%



K.M. Murphy, P. Travers and M. Walport. Janeway's Immunobiology. 8th Edition. 2012. Garland Publishing
ISBN: 9780815342434

Original research articles and review articles

Department Graduate Notes:

  • Students are advised to review the plagiarism tutorial found at
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Graduate Studies Notes:

Important dates and deadlines for graduate students are found here: http://www.sfu.ca/dean-gradstudies/current/important_dates/guidelines.html. The deadline to drop a course with a 100% refund is the end of week 2. The deadline to drop with no notation on your transcript is the end of week 3.

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html