Spring 2015 - MBB 762 G100

Human Genomics (3)

Class Number: 4017

Delivery Method: In Person


  • Course Times + Location:

    Jan 6 – Apr 13, 2015: Wed, Fri, 8:30–10:20 a.m.



The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues.


This course will focus on the organization of the human genome and the role of genome variation in health and disease. Ancillary topics of direct relevance to human genomics, such as personalized medicine and intellectual property will also be covered. Instruction will include lecture material and in-depth consideration of selected seminal papers in human genomics. Prerequisite: MBB 331

Topics will include the following:
·   Landscape of the human genome
·   Next generation sequencing: genomes, exomes, transcriptomes and other applications
·   Introduction to analysis of next-generation sequence data
·   Who owns your genome - genomics and intellectual property
·   Common polymorphism and complex disease
·   Rare genetic variation and disease gene hunting
·   Personalized medicine
·   Direct-to-consumer genetic testing
·   Prenatal testing/screening
·   Cancer genomes, transcriptomes and epigenomes
·   Genomics of the adaptive immune system
·   Ancient genomes and insights into human genetic history
·   Other current topics in human genomics


  • Three midterm exams (1 hour each) on lecture material & assigned reading 50%
  • One short (1-2 page) summary/critique of paper selected from primary literature 10%
  • Take-home assignment: accessing, manipulating and analyzing genomic data 10%
  • Take-home assignment on personal genome analysis 15%
  • Participation 5%
  • Selected topic presentation 10%



Terry A. Brown. Genomes 3, 3rd Edition. 2006.

Dudley & Karczewski. Exploring Personal Genomics. 2013.

Department Graduate Notes:

  • Students are advised to review the plagiarism tutorial found at
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Graduate Studies Notes:

Important dates and deadlines for graduate students are found here: http://www.sfu.ca/dean-gradstudies/current/important_dates/guidelines.html. The deadline to drop a course with a 100% refund is the end of week 2. The deadline to drop with no notation on your transcript is the end of week 3.

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html