Fall 2021 - MBB 328 D100

Introduction to Microbial Pathogenesis (3)

Class Number: 4470

Delivery Method: Remote


  • Course Times + Location:

    Sep 8 – Dec 7, 2021: Tue, Thu, 2:30–4:20 p.m.

  • Exam Times + Location:

    Dec 20, 2021
    Mon, 7:00–10:00 p.m.

  • Prerequisites:

    MBB 231 with a minimum grade of C.



The molecular strategies that bacterial and viral pathogens use to colonize the human body and cause disease will be studied. Emphasis will be placed on the specific microbes and their virulence factors, secretion systems, toxins and surface adhesions. Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail. Students with credit for MBB 428 may not take this course for further credit.



We will examine the molecular mechanisms by which microbial pathogens colonize the human body and cause disease. Emphasis will be placed on selected microbes and their structure/morphology, genetics, virulence factors, secretion systems, toxins and surface adhesions. Strategies for combating microbial infections, including antibiotics, antiviral agents and vaccines, will be discussed in detail. Students with credit for MBB 428 may not take this course for further credit.

Course Details:

Host immune response
Overview of virus structure

Selected viral pathogens:

- Polio virus

- Coronaviruses including SARS-CoV2
- Influenza virus

- Human immunodeficiency virus (HIV)

- Human papilloma virus (HPV)

- Herpes simplex virus (HSV)

Antiviral agents and resistance mechanisms

Selected bacterial pathogens:

- Listeria monocytogenes

- Streptococci, Enterococci, Staphylococcus aureus

- Pseudomonas aeruginosa

- pathogenic E. coli

- Klebsiella pneumoniae

Antibiotics and resistance mechanisms
Selected fungal pathogen & parasite

Human microbiota


  • Two midterm exams and a cumulative final exam 80%
  • Assignments 20%


Lecture:  blended (synchronous lectures, attendance is not mandatory; recorded and available
online for asynchronous viewing)
Tutorials:  synchronous
Assessments:  synchronous exams and asynchronous assignments
Final Exam:  synchronous (held during exam period)
Remote invigilation:  Possibly


  • access to high-speed internet
  • computer (webcam not needed)

Department Undergraduate Notes:

  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:


SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html


Teaching at SFU in fall 2021 will involve primarily in-person instruction, with approximately 70 to 80 per cent of classes in person/on campus, with safety plans in place.  Whether your course will be in-person or through remote methods will be clearly identified in the schedule of classes.  You will also know at enrollment whether remote course components will be “live” (synchronous) or at your own pace (asynchronous).

Enrolling in a course acknowledges that you are able to attend in whatever format is required.  You should not enroll in a course that is in-person if you are not able to return to campus, and should be aware that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes.

Students with hidden or visible disabilities who may need class or exam accommodations, including in the context of remote learning, are advised to register with the SFU Centre for Accessible Learning (caladmin@sfu.ca or 778-782-3112) as early as possible in order to prepare for the fall 2021 term.