Spring 2021 - MBB 433 D100
Epithelial Cell Biology (3)
Class Number: 2618
Delivery Method: In Person
Emerging concepts in epithelial cell biology, including the establishment and maintenance of epithelial cell polarity and cell adhesion leading to the sculpting of developing organisms, roles in wound healing, birth defects and microbial defense, and insights into the maintenance of epithelia by stem cells will be explored.
In this lecture/seminar course, we will examine the primary research literature on epithelial biology. Epithelia are critical tissues in the development and function of multicellular eukaryotes, and depend on the ability of epithelial cells to adhere to each other and form almost impermeable sheets. These sheets separate the inside of the body from the outside and separate different compartments of the body from each other. We will consider the remarkable plasticity of epithelia, examining how cell shape change and rearrangement in epithelia are used to sculpt developing organisms, and how failures in epithelial morphogenesis underlie many birth defects. We will examine how epithelial cells are generally polarized along the apicobasal axis and in the plane of the tissue. The repair and maintenance of epithelia are essential for organismal survival and we will examine how wound healing and epithelial stem cells keep these tissues functional. Classes will consist of lectures and student presentations and discussion of recent research articles.
Topics will include:
1. Evolution of epithelia
2. Techniques for studying epithelia
3. How to build an epithelium: emergence of apicobasal and planar cell polarity
4. How to bring an epithelium to its final form: epithelial morphogenesis
5. Breaking down and reassembling epithelia: epithelial-mesenchymal transition and mesenchymal-epithelial transition
6. Epithelial fusions: Developmental sealing of epithelia and wound healing
7. Maintaining an epithelium: epithelial stem cells
8. Epithelia and microbial defense
- Midterm Exam 20%
- Oral Presentation 25%
- Class Participation 20%
- Final term paper 35%
Lectures: blended (synchronous lectures, attendance is not mandatory; recorded and available online for asynchronous viewing)
- synchronous midterm exams (students must take exams during scheduled class time)
- blended; both synchronous (mandatory attendance) and asynchronous assessments
- oral presentations and written term paper
Final exam: synchronous (held during scheduled class time)
Remote invigilation: No
MATERIALS + SUPPLIES:
- access to high-speed internet
We will read review articles and primary research papers only. A basic cell biology textbook may be used by students as a refresher on certain topics.
Department Undergraduate Notes:
- For help with writing, learning and study strategies please contact the Student Learning Commons at
- Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail: firstname.lastname@example.org)
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS
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TEACHING AT SFU IN SPRING 2021
Teaching at SFU in spring 2021 will be conducted primarily through remote methods. There will be in-person course components in a few exceptional cases where this is fundamental to the educational goals of the course. Such course components will be clearly identified at registration, as will course components that will be “live” (synchronous) vs. at your own pace (asynchronous). Enrollment acknowledges that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes. To ensure you can access all course materials, we recommend you have access to a computer with a microphone and camera, and the internet. In some cases your instructor may use Zoom or other means requiring a camera and microphone to invigilate exams. If proctoring software will be used, this will be confirmed in the first week of class.Students with hidden or visible disabilities who believe they may need class or exam accommodations, including in the current context of remote learning, are encouraged to register with the SFU Centre for Accessible Learning (email@example.com or 778-782-3112).