Spring 2022 - MBB 427 D100

Immune Responses in Health and Disease (3)

Class Number: 2506

Delivery Method: In Person


  • Course Times + Location:

    Jan 10 – Apr 11, 2022: Wed, Fri, 2:30–4:20 p.m.

  • Prerequisites:

    One of MBB 326, HSCI 326, MBB 426 or HSCI 426, with a minimum grade of C, or permission of the instructor.



Defects in the immunologic response to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for HSCI 427 cannot take MBB 427 for credit.


Course Description
Many diseases are caused by inadequacy or dysregulation of the immune system.  This course will examine the immunological mechanisms underlying vaccination, primary human immunodeficiencies, HIV/AIDS, asthma and allergy, autoimmunity, and organ transplantation.  Immune responses to cancer and cancer immunotherapy will also be discussed. 

Lecture Topics

  1. Evasion and subversion of host defenses by pathogens
  2. Vaccines
  3. Primary human immunodeficiencies
  5. Allergy and hypersensitivity
  6. Induction and maintenance of tolerance
  7. Autoimmunity
  8. Transplantation
  9. Tumor immunology and immunotherapy


Understand the physiological, cellular, molecular and genetic bases of a range of immunopathologies. Develop insights into immunosurveillance and how cancer and organ transplantation overcome immune responses. Gain depth in the use of current technologies, including immunotherapies. Improve skills developed in MBB/HSCI 426/726 to review and critique papers in the primary literature, in both oral and written formats.


  • 2 non-cumulative exams (30% each) 60%
  • Tutorial participation 10%
  • Written summary and presentation 30%



Original research articles and review articles

The Immune System, 5th Ed., Peter Parham, 2021.  Norton.
ISBN: 978-0-393-53334-7

Department Undergraduate Notes:

  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:


SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html


Teaching at SFU in spring 2022 will involve primarily in-person instruction, with safety plans in place.  Some courses will still be offered through remote methods, and if so, this will be clearly identified in the schedule of classes.  You will also know at enrollment whether remote course components will be “live” (synchronous) or at your own pace (asynchronous).

Enrolling in a course acknowledges that you are able to attend in whatever format is required.  You should not enroll in a course that is in-person if you are not able to return to campus, and should be aware that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes.

Students with hidden or visible disabilities who may need class or exam accommodations, including in the context of remote learning, are advised to register with the SFU Centre for Accessible Learning (caladmin@sfu.ca or 778-782-3112) as early as possible in order to prepare for the spring 2022 term.