Spring 2023 - STAT 854 G100

Biometrics: Methods in Biomedical Studies (4)

Class Number: 5908

Delivery Method: In Person


  • Course Times + Location:

    Tu, Th 3:30 PM – 5:20 PM
    WMC 2268, Burnaby

  • Prerequisites:

    STAT 450 or permission of the instructor.



Principles, methods and applications of basic statistical approaches in biomedical studies are presented. Topics include introduction to epidemiology; design of cohort and case-control studies; experimental versus observational data, and cross-sectional versus longitudinal studies; issues of confounding, causation and missing data; design of clinical trials; data monitoring and interim analysis.


Course Outline:

  1. History of epidemiology, and commonly-used concepts and terminology in biomedical studies
  2. Measures of disease occurrence and association. 
  3. Design of medical studies: cohort and case-control studies; controlled clinical experiments. 
  4. Models and analysis in prospective and retrospective studies.  
  5. Clinical trial design principles: bias control, random error control, randomization, blocking, masking 
  6. Types of clinical trials: phases of trial, translational, dose-finding, cross-over, safety and efficacy, and comparative trials. 
  7. Study monitoring: sequential methods.
  8. Selected important topics in biostatistics: survival analysis, longitudinal analysis, missing data, causal inference


  • Assignments 30%
  • Projects 50%
  • Final Presentation 20%


All grading is subject to change.



Access to high-speed internet, webcam.


Epidemiologic Methods: Studying the Occurrence of Illness, 2nd ed. Authors: Noel S. Weiss and Thomas D. Koepsell. Publisher: Oxford University Press
ISBN: 9780195314465

Clinical Trials: A Methodologic Perspective, Second Edition. Author: Steven Piantadosi. Publisher: Wiley
ISBN: 9780471727811

Fundamentals of Clinical Trials, 5th ed. Authors: L.M. Friedman, C.D. Furberg, D. DeMets, D.M. Reboussin, C.B. Granger. Publisher: Springer
ISBN: 9783319185385


Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Graduate Studies Notes:

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Registrar Notes:


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