Spring 2015 - MBB 762 G100
Human Genomics (3)
Class Number: 4017
Delivery Method: In Person
The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues.
This course will focus on the organization of the human genome and the role of genome variation in health and disease. Ancillary topics of direct relevance to human genomics, such as personalized medicine and intellectual property will also be covered. Instruction will include lecture material and in-depth consideration of selected seminal papers in human genomics. Prerequisite: MBB 331
Topics will include the following:
· Landscape of the human genome
· Next generation sequencing: genomes, exomes, transcriptomes and other applications
· Introduction to analysis of next-generation sequence data
· Who owns your genome - genomics and intellectual property
· Common polymorphism and complex disease
· Rare genetic variation and disease gene hunting
· Personalized medicine
· Direct-to-consumer genetic testing
· Prenatal testing/screening
· Cancer genomes, transcriptomes and epigenomes
· Genomics of the adaptive immune system
· Ancient genomes and insights into human genetic history
· Other current topics in human genomics
- Three midterm exams (1 hour each) on lecture material & assigned reading 50%
- One short (1-2 page) summary/critique of paper selected from primary literature 10%
- Take-home assignment: accessing, manipulating and analyzing genomic data 10%
- Take-home assignment on personal genome analysis 15%
- Participation 5%
- Selected topic presentation 10%
Terry A. Brown. Genomes 3, 3rd Edition. 2006.
Dudley & Karczewski. Exploring Personal Genomics. 2013.
Department Graduate Notes:
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Graduate Studies Notes:
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