Fall 2016 - MBB 722 G100
Biological Membranes (3)
Class Number: 1434
Delivery Method: In Person
Course Times + Location:
We, Fr 8:30 AM – 10:20 AM
SECB 1014, Burnaby
Exam Times + Location:
Dec 17, 2016
12:00 PM – 3:00 PM
AQ 5016, Burnaby
1 778 782-3709
A review of recent literature on the structure, dynamics, function and biosynthesis of membrane lipids and proteins.
Grounding in the principles of membrane organization and a review of recent research on the structure, dynamics and function of membranes, membrane lipids and proteins.
4 lecture hours/week; 0 tutorial hour/week; 0 lab hours
1. Paradigms of membrane organization and physical properties, chemical structures of lipids; hydrophobic effect, model membranes
2. Membrane Lipid dynamics and phase properties, effects of cholesterol
3. Characterization of membranes using physical techniques: diffraction, magnetic resonance (NMR/ESR)
4. Lipid Polymorphism, shape theory
5. Protein rotational and translational dynamics
6. Membrane surface potential
7. Membrane asymmetry and lipid microdomains (RAFTS) – methods, characterization and function(s)
8. Topography analysis of integral membrane proteins
· hydropathy analysis
· helix-helix interactions
· folding and insrtion pathways for helix bundles and beta barrels
9. Integral membrane protein – lipid interactions: principles
10. Modulation of integral membrane protein conformation by specific lipid or ligand interactions
· mechanosensitive ion channels
· voltage-gated ion channels
11. Peripheral membrane proteins, structure and lipid interactions
· Lipid covalent anchors
· Lipid binding modules: amphipathic helix anchors
12. Peripheral proteins perturb lipid bilayers - curvature induction; fusion
- Assignments 40%
- One in-class presentation 20%
- Attendance/participation 10%
- Research paper on same topic as presentation 30%
A course in protein structure/function is highly recommended.
Luckey, Mary, Membrane Structural Biology with Biochemical and Biophysical Foundations, 2nd Ed., 2014. Cambridge University Press.
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