Spring 2021 - BPK 448 D100
Rehabilitation of Movement Control (3)
Class Number: 7524
Delivery Method: In Person
Course Times + Location:
We 11:30 AM – 12:20 PM
REMOTE LEARNING, Burnaby
Fr 10:30 AM – 12:20 PM
REMOTE LEARNING, Burnaby
Exam Times + Location:
Apr 25, 2021
12:00 PM – 2:00 PM
REMOTE LEARNING, Burnaby
1 778 782-3141
Office: L 9003
Prerequisites:BPK 201 or 207, and BPK 306, or for biomedical engineering students, BPK 201, 208 and 308.
This course is aimed at students interested in neuromuscular rehabilitation. Students will learn about the pathological origins of movement disorders associated with impaired function of sensory and motor systems. The course will be focused on the stages and strategies for recovery of voluntary control of essential functions. The range of rehabilitation interventions available to assist recovery and restore voluntary control will be explored, with special emphasis on advanced techniques to restore control of movement and bodily functions in paralyzed people.
13 weeks x 3 Lecture hours per week (1 hour on Wednesdays, 2 hours on Fridays)
Target students are senior biomedical physiology, kinesiology and biomedical engineering majors interested in
1) The human body’s intrinsic capacity and physiological limitations for recovery from severe neurological trauma or disease that cause paralysis, movement disorders and/or sensory deficits
2) Current and emerging approaches to restore, augment or replace the functions of affected muscles or organs
3) Insights on clinical trials, regulatory requirements & commercialization pathway for innovative therapies.
The course explores a wide range of rehabilitation options and their risks, ethics, costs & benefits.
Emphasis will be placed on advanced neuroprosthetic therapies that use targeted electrical stimulation to protect, restore or enhance voluntary control of basic functions and/or support independence in activities of daily living.
TOPICS: Review of neuromuscular mechanisms for normal movement control Pathologies that affect sensory and motor functions Brain, spinal cord, spinal roots, peripheral nerves, muscles; somatic & autonomic Capacity for self‐repair and regeneration after injury of peripheral vs. central neural systems
Classification standards for impairment vs. disability
Approaches to restoring or replacing lost or diminished neuromuscular function
Physiotherapy ‐ pharmacotherapy ‐ surgical reconstruction ‐ targeted electrical stimulation
Neural prostheses Guidelines for safe and effective electrical stimulation of excitable tissues Approaches designed for temporary or permanent interfacing with the nervous system External vs. partially implanted vs. fully implanted neurostimulation systems Neuromodulation for treatment of chronic pain, movement disorders or other neurological disorders Preventing or restoring impaired motor/sensory function with functional electrical stimulation Neuroprosthetic approaches for voluntary control of artificial limbs
Open‐loop vs. closed‐loop control
Tapping available command signal sources for prosthesis control
Sensors and sensory feedback sources for prosthesis control
The path to commercialization of therapeutic innovations
R&D, funding sources, pre‐clinical & clinical validation of safety & efficacy, regulatory approval Determinants of commercial viability and market success Functionality vs. availability vs. cost: meeting expectations of patients, physicians and payers Acute vs. chronic consequences of neurological injury or disease
Assessment of functional loss
COURSE-LEVEL EDUCATIONAL GOALS:
Describe differences and similarities in the regenerative capacity of peripheral neurons vs. central neurons after injury.
Describe reasons for differences in the acute and chronic consequences of brain injuries.
Discuss current classification standards for impairment vs. disability after injury or disease.
Design basic therapeutic plans for restoring or replacing lost neuromuscular functions using physiotherapy, pharmacotherapy, reconstructive surgery and/or targeted electrical stimulation.
Apply accepted guidelines for safe and effective electrical stimulation of excitable tissues.
Assess the relative benefits and drawbacks of neurostimulation systems that use external vs. partially implanted vs. fully implanted components.
Describe current uses of neuromodulation for treatment of chronic pain, epilepsy or movement disorders.
Evaluate possibilities for using neuromodulation to treat additional neurological disorders.
Describe uses of functional electrical stimulation to protect muscles from disuse atrophy or to rebuild muscle strength in disused muscles.
Describe neuroprosthetic systems that enhance voluntary control of artificial limbs by amputees.
Explain the roles and uses of sensors and sensory feedback for prosthesis control.
Describe regulatory requirements to develop, test and commercialize a therapeutic innovation.
Analyze the basic determinants of commercial viability and marketing success for a new therapy.
Apply knowledge learned in class to diagnose and “treat” new patient scenarios in exams.
Apply knowledge learned in class to evaluate a new therapeutic solution that may be first described in an exam question.
Course marks will be based on the best 2 out of 3 Midterm scores (adjusted to 60%) plus the final exam (40%). All Exams will be taken synchronously at the posted dates and times and will be monitored via Zoom.
The instructor will regularly communicate with the students via email.
Lecture Slides, Supplementary Notes and Reading Materials will be posted weekly by the instructor in the course website.
Review articles, suggested background articles, news will be posted by instructor in the course website and/or distributed by email.
Department Undergraduate Notes:
It is the responsibility of the student to keep their BPK course outlines if they plan on furthering their education.
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS
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TEACHING AT SFU IN SPRING 2021
Teaching at SFU in spring 2021 will be conducted primarily through remote methods. There will be in-person course components in a few exceptional cases where this is fundamental to the educational goals of the course. Such course components will be clearly identified at registration, as will course components that will be “live” (synchronous) vs. at your own pace (asynchronous). Enrollment acknowledges that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes. To ensure you can access all course materials, we recommend you have access to a computer with a microphone and camera, and the internet. In some cases your instructor may use Zoom or other means requiring a camera and microphone to invigilate exams. If proctoring software will be used, this will be confirmed in the first week of class.Students with hidden or visible disabilities who believe they may need class or exam accommodations, including in the current context of remote learning, are encouraged to register with the SFU Centre for Accessible Learning (email@example.com or 778-782-3112).