Sivak Group

The Sivak group uses theory and computation to study the nonequilibrium thermodynamics of molecular-scale biological processes. We seek to identify the physical constraints placed on biological systems by their operational imperatives: performing productive functions in finite time while driven by strong gradients, using fluctuation-dominated microscopic objects of low copy number in a cell at room temperature. Such constraints should point to the basic design principles of driven biomolecular-scale energy and information transmission, illuminate the (constrained) evolutionary optimization of molecular machines and cellular networks, and produce criteria for achieving particular functions in novel synthetic machines and networks.