SFU.CA Burnaby | Surrey | Vancouver
|
SFU Search

Rosemary Cornell - Selected Publications

  • Cornell, R. B. (2016) Membrane lipid compositional sensing by the inducible amphipathic helix of CCT. Biochim. Biophys. Acta, in press.
  • Cornell, R. B., Ridgway, N.D. (2015) CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis. Biochemistry 53: 450-461.
  • Lee, J., Taneva, S.G., Holland, B., Tieleman, D.P., and Cornell, R.B. (2014) Structural basis for auto-inhibition of CTP: phosphocholine cytidylyltransferase (CCT), the regulatory enzyme in phosphatidylcholine synthesis. Prog. Lipid. Res. 59: 147-171.
  • Chong, S. H., Taneva, S.G., Lee, J.M.C., and Cornell, R.B. (2014) The curvature sensitivity of membrane-binding amphipathic helices can be modulated by the charge on a flanking region. Biochemistry 53: 450-461.
  • Huang, H.K-H., Taneva, S.G., Lee, J., Silva, L.P., Schriemer, D.C., and Cornell, R.B. (2013) The membrane-binding domain of an amphitropic enzyme suppresses catalysis by interaction with an amphipathic helix flanking its active site. J. Mol. Biol. 425: 1546-1564.
  • Ding, Z., Taneva, S.G., Huang, H. K-H, Campbell, S.A., Semenec, L., Chen, N., Cornell, R.B. (2012) A 22mer segment in the structurally pliable regulatory domain of metazoan CTP: phosphocholine cytidylyltransferase facilitates both silencing and activating functions. J. Biol. Chem. 286: 38980-38991.
  • Taneva, S.G. Lee, J.M.C. Cornell, R.B. (2012) The amphipathic helix of an enzyme that regulates phosphatidylcholine synthesis remodels membranes into highly curved nanotubules. Biochim. Biophys. Acta -Biomembranes, 1818:1173-1186.
  • Dennis, M.K., Taneva, S.G., Cornell, R.B. (2011) The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoforms. J. Biol. Chem. 286: 12349-12360.
  • Zahedi, B., Beaulieu, N., Goo, H-J., Kay R. J., Cornell, R.B. (2011) Phosphoinositide detection by RasGRP1 directly couples the PI 3-kinase and Ras signaling pathways at the plasma membrane. J. Biol. Chem. 286:12712-12723.
  • Jaeyong Lee, J.E. Johnson, Z. Ding, M. Paetzel, R. B. Cornell (2009) Crystal Structure of CTP:phosphocholine cytidylyltransferase catalytic domain novel catalytic residues within a highly conserved transferase active site fold. J. Biol. Chem. 284: 33535-33548.
  • Taneva, S.G., Dennis, M.K., Ding, Z., Smith, J.L., Cornell, R.B. (2008) Contribution of each membrane binding domain of the CTP: Phosphocholine Cytidylyltransferase-a dimer to its activation, membrane binding, and membrane cross-bridging. J. Biol. Chem. 283: 28137-28148.
  • Gehrig, K., Cornell, R.B., Ridgway, N. (2008) Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase-a. Molec. Biol. Cell. 19: 237-47.
  • Cornell, R.B. and Taneva, S. (2006) Amphipathic helices as mediators of the membrane interaction of amphitropic proteins, and as modulators of bilayer physical properties. Current Peptide and Protein Research7: 539-552.
  • Kitos,T.E., Choy, C.M.Y., and Cornell, R.B. (2006) Angiotensin stimulates phosphatidylcholine
  • synthesis via a pathway involving diacylglycerol, protein kinase C, ERK1/2, and CTP: phosphocholine cytidylyltransferase. Biochim. Biophys. Acta.,1761: 272-279.
  • Bogan, M.J., Agnes, G.R., Pio, F., Cornell, R.B. (2005) Interdomain and membrane interactions of CTP: Phosphocholine Cytidylyltransferase revealed via limited proteolysis and mass spectrometry.  J. Biol. Chem.280: 19613 - 19624.
  • Taneva, S., Johnson, J.E., and Cornell, R.B.* (2003) Lipid-Induced Conformational Switch in the Membrane Binding Domain of CTP:Phosphocholine Cytidylyltransferase: A Circular Dichroism Study. Biochemistry42, 11768-11776.
  • Johnson, J.E., Xie, M., Singh, L., Edge, R., & Cornell, R.B.* (2003) Both acidic and basic amino acids in an amphitropic enzyme dictate its selectivity for anionic membranes. J. Biol. Chem. 278: 514-522.
  • Cornell, R.B.* & Northwood, I.C. (2000) Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem. Sci. 25: 441-447.

Last Update - Jan 2015