Spring 2021 - MBB 728 G100
Microbial Pathogenesis (3)
Class Number: 7050
Delivery Method: In Person
The molecular strategies that bacterial and viral pathogens use to colonize the human body and cause disease will be studied. Emphasis will be placed on specific microbes and their virulence factors, secretion systems, toxins and surface adhesins. Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail. Students with credit for MBB 420, MBB 428, MBB 829, or BISC 820 under the same title of this course may not take this course for further credit.
The molecular strategies that bacterial and viral pathogens use to colonize the human body and cause disease will be studied. Emphasis will be placed on the specific microbes and their virulence factors, secretion systems, toxins and surface adhesions. Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail.
This is a lecture-based course with three 50-minute lectures each week. Lecture topics include bacterial and viral biology and structure, virulence mechanisms and host response, as well as antibiotics, antiviral agents and vaccines and the role of the human microbiota in health and disease. Lectures will focus on individual pathogens and the diseases they cause. An emphasis will be placed on the structural biology of these virulence systems. Students are expected to attend all lectures, to give two presentations on high impact papers from current literature, and write a term paper. Students who have taken MBB 420, MBB 428, BISC 889, or BISC 820 under the same title cannot take this course for further credit.
Lecture topics may include:
Host immune response
Overview of virus structure
- Influenza virus
- Human immunodeficiency virus (HIV)
- Ebola virus
- Variola (smallpox)
- Human papilloma virus (HPV)
- Herpes simplex virus (HSV)
- Listeria monocytogenes
- Mycobacterium tuberculosis
- Bacillus anthracis
- Streptococci, Enterococci, Staphylococcus aureus
- Pseudomonas aeruginosa
- pathogenic E. coli
- Vibrio cholerae
- pathogenic Neisseria
- Helicobacter pylori
Antibiotics and resistance
- Presentations 70%
- Term paper 30%
Lecture: blended (synchronous lectures, attendance is not mandatory; recorded and available
online for asynchronous viewing)
Assessments: blended; both synchronous (mandatory attendance) and asynchronous assessments
- access to high-speed internet
- computer (webcam not needed)
Graduate Studies Notes:
Important dates and deadlines for graduate students are found here: http://www.sfu.ca/dean-gradstudies/current/important_dates/guidelines.html. The deadline to drop a course with a 100% refund is the end of week 2. The deadline to drop with no notation on your transcript is the end of week 3.
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS
SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.
Each student is responsible for his or her conduct as it affects the University community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html
TEACHING AT SFU IN SPRING 2021
Teaching at SFU in spring 2021 will be conducted primarily through remote methods. There will be in-person course components in a few exceptional cases where this is fundamental to the educational goals of the course. Such course components will be clearly identified at registration, as will course components that will be “live” (synchronous) vs. at your own pace (asynchronous). Enrollment acknowledges that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes. To ensure you can access all course materials, we recommend you have access to a computer with a microphone and camera, and the internet. In some cases your instructor may use Zoom or other means requiring a camera and microphone to invigilate exams. If proctoring software will be used, this will be confirmed in the first week of class.Students with hidden or visible disabilities who believe they may need class or exam accommodations, including in the current context of remote learning, are encouraged to register with the SFU Centre for Accessible Learning (email@example.com or 778-782-3112).