Jamie Scott

Professor, Faculty of Health Sciences

Canada Research Chair Tier 1 in Molecular Immunity

 

Education

  • AB, Biological Sciences, Occidental College, Los Angeles
  • MD, Saint Louis University of Medicine, Missouri
  • PhD, Biological Sciences, University of Missouri-Columbia
  • Postdoctoral experience in genetic toxicology, Massachusetts Institute of Technology; Biological Sciences, University of Missouri-Columbia; and Molecular Biology, The Scripps Research Institute

Biography

Dr. Scott is a Professor with a Joint Appointment between the Faculty of Health Sciences and the Department of Molecular Biology and Biochemistry.

Dr. Scott received her PhD for work on the germline immunoglobulin V genes. She attended medical school with the goal of becoming an academic biomedical researcher. Her postdoctoral research included projects to analyze the spectra of mutational hot-spots (W.G. Thilly), the development of the first phage-displayed peptide libraries and their use in analyzing antibody specificity (G.P. Smith) and in developing peptide mimics of a discontinuous protein epitope (E.D. Getzoff & J.A. Tainer). She began working at SFU in 1993 as an Assistant Professor in the Dept. of Chemistry and Member of the Institute of Molecular Biology & Biochemistry at SFU. (The Institute became a Department in SFU's Faculty of Science in 2001.) Dr. Scott was promoted to Associate Professor in 1998 and to Professor in 2002. In 2004, Dr. Scott began a joint appointment in the newly-formed Faculty of Health Sciences, as one of its founding faculty members. That year, she was awarded a Canada Research Chair in Molecular Immunity.

Research Interests

As a molecular immunologist and physician, Dr. Scott is interested in the peptide recognition profile of antibody responses, particularly those elicited by natural infection and vaccination, and their application in the development of vaccines. One of her research goals is to create a protective vaccine that will elicit broadly-neutralizing antibodies against HIV-1.

Dr Scott’s work focuses on the molecular basis for antigen recognition by antibodies using peptides as probes of these interactions. With peptide libraries, she has investigated the molecular basis of peptide mimicry, and the ability of select peptides to induce antibody responses that recognize a target antigen. She is applying this approach to better understand the antibody response during HIV-1 infection, and to design vaccines that will target the production of neutralizing antibodies against conserved sites on HIV-1.

Publications and Activities

Funding