- B.Sc., Polytechnic Faculty, Hogeschool Rotterdam (University of Applied Sciences), The Netherlands
- Ph.D., University of Leiden, The Netherlands/Research Center Borstel, Germany
Dr. Pantophlet is an Associate Professor in the Faculty of Health Sciences and an Associate Faculty member of the Department of Molecular Biology and Biochemistry. Dr. Pantophlet joined the Faculty of Health Sciences in 2008 and heads the Laboratory of Infectious Diseases Immunology.
Dr. Pantophlet received his B.Sc. degree in medical microbiology from the Hogeschool Rotterdam & Omstreken (The Netherlands) (1995) and his Ph.D. degree from the University of Leiden (The Netherlands) (1999) for his work on the immunochemical properties of Acinetobacter lipopolysaccharides (performed at the Research Center Borstel, Germany). He moved to The Scripps Research Institute in California (2000) for postdoctoral research on anti-HIV antibodies and vaccine design under the mentorship of Dr. Dennis Burton. Dr. Pantophlet returned to the Research Center Borstel for a brief postdoctoral period (2002) and then rejoined the Burton laboratory as a senior postdoctoral fellow to focus on HIV vaccine design (2003).
Research work in Dr. Pantophlet's laboratory is focused on investigating antibody responses to HIV and other viruses of biomedical interest, particularly in the context of host-virus interactions and anti-viral antibody responses. Knowledge gained from studying the interactions of antibodies with viruses will be applied to the 'rational' design of immunogens that may be developed into modern pre-clinical vaccine candidates and, ultimately, new and better vaccines. Techniques based on various scientific disciplines, including molecular biology, virology, biochemistry, and immunochemistry, are strongly applied in the laboratory.
For more information visit the Pantophlet Lab website.
Dr. Pantophlet's teaching interests include humoral immunology (B-cells, antibodies), antiviral antibody responses, and HIV/AIDS.
View Dr. Ralph Pantophlet's publications here.
- Probing Biased Recognition of Flu Hemagglutinin by Precursors of Broadly Neutralizing Antibodies to the HA Stem
- Synthetic bacterial analogs of mammalian oligomannose for eliciting neutralizing antibodies to the high mannose patch on HIV Env
- A bacterially derived mimetic of mammalian oligomannose for eliciting anti-HIV glycan antibodies
- Exploring immunogen requirements for the priming of hetero-subtypic neutralizing antibodies to flu
- Barriers to engaging young people in HIV vaccine trials in a priority setting